Effect of oxametacin on endogenous uric acid clearance rate in healthy volunteers
| Autor: | F Deger, J Douchamps, J Broekhuysen, H Ducarne, J Polderman, André Herchuelz |
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| Rok vydání: | 1983 |
| Předmět: |
Adult
Male musculoskeletal diseases Metabolic Clearance Rate Indomethacin Analgesic Anti-Inflammatory Agents Allopurinol Endogeny Pharmacology Benzbromarone chemistry.chemical_compound Humans Medicine Pharmacology (medical) Antipyretic business.industry nutritional and metabolic diseases General Medicine Oxametacin medicine.disease Uric Acid Gout chemistry Creatinine Uric acid Female business medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 24:671-673 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/bf00542220 |
| Popis: | Oxametacin, a new non steroidal anti-inflammatory compound, with analgesic, antipyretic and anti-inflammatory properties comparable to those of indomethacin, has been claimed to be effective in treatment of acute attacks of gout. The present study comprises an investigation in 8 healthy volunteers of the effect on the endogenous uric acid clearance rate, of oxametacin administered alone or in combination with the conventional hypouricaemic agents benzbromarone or allopurinol. Whether given alone or in combination with these drugs, oxametacin failed to alter the clearance rate of endogenous uric acid. In view of its good tolerance and its possible efficacy in treatment of acute attacks of gout, the present data help to validate use of oxametacin in acute gout. |
| Databáze: | OpenAIRE |
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