HMDB: a knowledgebase for the human metabolome
| Autor: | Jianguo Xia, Paul Huang, Rustem Shaykhutdinov, Andrea De Souza, Dean Cheng, Leslie Jia, Ian J. Forsythe, Liang Li, Jun Peng, Souhaila Bouatra, Bijaya Gautam, Savita Shrivastava, Melisa Clements, David Hau, Joseph A. Cruz, Hans J. Vogel, Constance A. Sobsey, Derrick L. J. Clive, Ryan Fradette, Nelson Young, Philip Liu, Avalyn Lewis, Dan Tzur, Roman Eisner, Rupasri Mandal, Margot Dawe, Alsu Nazyrova, Nick Psychogios, Lydia Fang, Edison Dong, Igor Sinelnikov, David S. Wishart, Azaret Zuniga, Yeping Xiong, Craig Knox, An Chi Guo, Emilia L. Lim, Russell Greiner |
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| Rok vydání: | 2008 |
| Předmět: |
Magnetic Resonance Spectroscopy
Databases Factual Systems biology Biology Bioinformatics 01 natural sciences Clinical biochemistry Mass Spectrometry 03 medical and health sciences User-Computer Interface Metabolomics Genetics Metabolome Humans Human Metabolome Database Data content Clickable 030304 developmental biology Text searching 0303 health sciences Information retrieval 010401 analytical chemistry Articles 0104 chemical sciences Metabolic Networks and Pathways |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 |
| Popis: | The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Since its first release in 2007, the HMDB has been used to facilitate the research for nearly 100 published studies in metabolomics, clinical biochemistry and systems biology. The most recent release of HMDB (version 2.0) has been significantly expanded and enhanced over the previous release (version 1.0). In particular, the number of fully annotated metabolite entries has grown from 2180 to more than 6800 (a 300% increase), while the number of metabolites with biofluid or tissue concentration data has grown by a factor of five (from 883 to 4413). Similarly, the number of purified compounds with reference to NMR, LC-MS and GC-MS spectra has more than doubled (from 380 to more than 790 compounds). In addition to this significant expansion in database size, many new database searching tools and new data content has been added or enhanced. These include better algorithms for spectral searching and matching, more powerful chemical substructure searches, faster text searching software, as well as dedicated pathway searching tools and customized, clickable metabolic maps. Changes to the user-interface have also been implemented to accommodate future expansion and to make database navigation much easier. These improvements should make the HMDB much more useful to a much wider community of users. |
| Databáze: | OpenAIRE |
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