Sex-specific impact of anthropometric parameters on outcomes after transcatheter edge-to-edge repair for secondary mitral regurgitation
| Autor: | Satoshi Higuchi, Mathias Orban, Marianna Adamo, Cristina Giannini, Bruno Melica, Nicole Karam, Fabien Praz, Daniel Kalbacher, Edith Lubos, Lukas Stolz, Daniel Braun, Michael Näbauer, Mirjam Wild, Philipp Doldi, Michael Neuss, Christian Butter, Mohammad Kassar, Tobias Ruf, Aniela Petrescu, Niklas Schofer, Roman Pfister, Christos Iliadis, Matthias Unterhuber, Holger Thiele, Stephan Baldus, Ralph Stephan von Bardeleben, Steffen Massberg, Stephan Windecker, Philipp Lurz, Anna Sonia Petronio, Marco Metra, Jörg Hausleiter |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Aged 80 and over Heart Valve Prosthesis Implantation Heart Failure Cardiac Catheterization Obesity paradox Mitral Valve Insufficiency Middle Aged Sex difference Heart failure Secondary mitral regurgitation Transcatheter edge-to-edge repair Treatment Outcome Humans Mitral Valve Female Cardiology and Cardiovascular Medicine 610 Medizin und Gesundheit Aged |
| DOI: | 10.48350/173029 |
| Popis: | BACKGROUND Body surface area (BSA) has been reported to be the stronger predictor for prognosis than body mass index in heart failure (HF) patients. The sex-specific association of BSA with mortality has been unclear. METHODS EuroSMR, a European multicenter registry, included patients who underwent edge-to-edge repair (TEER) for secondary mitral regurgitation (SMR). The outcome was two-year all-cause mortality. RESULTS The present cohort included 1594 HF patients (age, 74 ± 10 years; male, 66%). Association of calculated BSA with two-year all-cause mortality was evaluated. Patients were classified into three BSA groups: the lowest 10% (S), the highest 10% (L), and intermediate between S and L (M). Mean BSA was 1.87 ± 0.21 m2 (male, 1.94 ± 0.18 m2; female, 1.73 ± 0.18 m2). The association of BSA with the endpoint in females showed a U-shaped curve, indicating worse prognosis for both S and L. The association in males followed a linear regression, demonstrating better prognosis for L. Hazard ratio (HR) of L to S in males was 0.43 (95% confidence interval [CI], 0.25-0.74; p = 0.002), whereas HR of L to M in females was 1.76 (95% CI, 1.11-2.78; p = 0.016) (p for interaction = 0.003). CONCLUSIONS Sex-specific association patterns demonstrate the complex influence of anthropomorphic factors in HF patients scheduled for TEER. Further investigation beyond simple evaluation of weight and height is needed for better comprehension of the obesity paradox and better prediction of the results of transcatheter therapy in HF patients. |
| Databáze: | OpenAIRE |
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