Treatment of epilepsy with clonazepam and its effect on other anticonvulsants
| Autor: | H J Keogh, R. H. Johnson, D. G. Lambie, R N Nanda, I D Melville |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Adolescent Myoclonic Jerk Epilepsies Myoclonic Clonazepam Epilepsy Photosensitive epilepsy Double-Blind Method medicine Ambulatory Care Humans Drug Interactions Focal Epilepsies Child Benzodiazepinones Clinical Trials as Topic business.industry musculoskeletal neural and ocular physiology Brain medicine.disease Clinical trial Hospitalization Psychiatry and Mental health Epilepsy Absence Epilepsy Temporal Lobe Anesthesia Phenobarbital Drug Evaluation Surgery Female Neurology (clinical) Epilepsies Partial Open label business Photic Stimulation medicine.drug Research Article |
| Zdroj: | Journal of neurology, neurosurgery, and psychiatry. 40(6) |
| ISSN: | 0022-3050 |
| Popis: | Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial. Considerable improvement occurred with patients with myoclonic jerks and tonic-clonic convulsions, and with photosensitive epilepsy. Patients with atypical petit mal and focal epilepsies also improved. Drowsiness was initially common but lasted only a short time. No evidence was found for an action of clonazepam on the metabolism of other drugs, but treatment with phenobarbitone lowered serum concentrations of clonazepam. We conclude that clonazepam is particularly valuable in epilepsy with associated myoclonsu and in photosensitive epilepsy. |
| Databáze: | OpenAIRE |
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