Prevalence and factors associated with faecal carriage of extended-spectrum β-lactamase-producing Enterobacterales among peripartum women in the community in Cambodia

Autor: Agathe, de Lauzanne, Navin, Sreng, Elsa, Foucaud, Touch, Sok, Thida, Chon, Chhaily, Yem, Veasna, Hak, Sothada, Heng, Meng, Soda, Malika, Gouali, Maya, Nadimpalli, Malin, Inghammar, Mamitina Alain Noah, Rabenandrasana, Jean Marc, Collard, Muriel, Vray, Simon Le, Hello, Alexandra, Kerleguer, Patrice, Piola, Elisabeth, Delarocque-Astagneau, Didier, Guillemot, Bich Tram, Huynh, Laurence, Borand, Armya Abdou, Youssouf
Přispěvatelé: Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Cambodian Communicable Disease Control Department, Institut Pasteur [Paris] (IP), Tufts University [Medford], Lund University [Lund], Institut Pasteur de Madagascar, Institut Pasteur de Dakar, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Saclay, Hôpital Raymond Poincaré [AP-HP], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), This work was supported by MSDAVENIR and Institut Pasteur., The authors thank Philippe Dussart and Sivuth Ong (Virology Unit, Institut Pasteur du Cambodge) for assistance with PCR and their availability, all BIRDY field monitors for questionnaire administration and sampling management, and Siyin Lach and Long Pring for their involvement in the BIRDY program. We are grateful to all women participating in the BIRDY program. We thank all collaborators of the BIRDY study group., Members of the BIRDY study group: Andrianirina Zafitsara Zo, Marguerite Diatta, Jean Baptiste Diouf, Fatoumata Diene Sarr, Joseph Faye, Sophie Goyet, Perlinot Herindrainy, Elsa Kermorvant-Duchemin, Siyin Lach, Veronique Ngo, Michael Padget, Feno Manitra Jacob Rakotoarimanana, Bodonirina Tanjona Raheliarivao, Frédérique Randrianirina, Abdoulaye Seck, Arnaud Tarantola and Armya Abdou Youssouf., Bich-Tram, Huynh
Rok vydání: 2022
Předmět:
Zdroj: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, 2022, 77 (10), pp.2658-2666. ⟨10.1093/jac/dkac224⟩
ISSN: 1460-2091
0305-7453
DOI: 10.1093/jac/dkac224⟩
Popis: Background In Southeast-Asia, where many conditions associated with dissemination of ESBL-producing Enterobacterales (ESBL-E) in the community are met, data from the community are scarce but show high ESBL-E carriage prevalence. Maternal ESBL-E colonization is considered a risk factor for neonatal colonization, which is the first step towards developing neonatal sepsis. Despite this, ESBL-E carriage prevalence and its risk factors during pregnancy or postpartum remain undefined in Southeast-Asia. Objectives To estimate the prevalence of ESBL-E faecal colonization among peripartum women in the community of an urban and a rural area in Cambodia, to investigate ESBL-E genomic characteristics and to identify associated risk factors. Methods Epidemiological data and faecal samples from 423 peripartum women were collected in an urban and rural areas in Cambodia (2015–16). Bacterial cultures, antibiotic susceptibility tests and ESBL gene sequencing were performed. Risk factor analysis was conducted using logistic regression. Results The prevalence of ESBL-E faecal carriage was 79.2% (95% CI 75.0%–82.8%) among which Escherichia coli (n = 315/335, 94.0%) were most frequent. All isolates were multidrug resistant. Among 318 ESBL-E, the genes most frequently detected were blaCTX-M-15 (41.5%), blaCTX-M-55 (24.8%), and blaCTX-M-27 (15.1%). Low income, undernutrition, multiparity, regular consumption of pork, dried meat, and raw vegetables, were associated with ESBL-E faecal carriage. Conclusions The high prevalence of ESBL-E carriage observed among peripartum women in Southeast-Asia and the identified associated factors underline the urgent need for public health measures to address antimicrobial resistance, including a ‘One Health’ approach.
Databáze: OpenAIRE
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