Clinical Characteristics of Patients with co-Existent Diabetic Peripheral Neuropathy and Depression: A Systematic Review
| Autor: | Ioannis Ioannidis, Maria Zafeiri, George Dimitriadis, Philip P Manolopoulos, Zoe Kleinaki, Constantinos Tsioutis |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Comorbidity Nephropathy Diabetes Complications Coronary artery disease Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetic Neuropathies Quality of life Risk Factors Internal medicine Diabetes mellitus Internal Medicine Humans Medicine Depression (differential diagnoses) Aged Depressive Disorder Major Depression business.industry General Medicine Middle Aged medicine.disease 030104 developmental biology Peripheral neuropathy Major depressive disorder business Retinopathy |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 129:77-85 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/a-0741-6937 |
| Popis: | Objectives Both diabetic peripheral neuropathy and depression have significant implications on patients’ quality of life, management and outcomes. We aimed to evaluate all available evidence concerning patients with co-existent diabetic peripheral neuropathy and depression, and describe their clinical characteristics, in order to promote early recognition and management. Methods Systematic search of PubMed for studies providing data on patients with diabetic peripheral neuropathy and depression. The primary outcome was to evaluate all available evidence related to characteristics of diabetes, diabetic peripheral neuropathy and depression. Secondary study outcomes included comorbid conditions and complications in these patients. Results Final analysis included 24 studies with data on 205 patients. Most patients were adults between 18–65 years of age. Mean HbA1c value was above 8% and most patients were treated with insulin. Neuropathy was predominantly painful and most patients with available data were considered to have major depressive disorder. In addition to diabetic peripheral neuropathy and depression, diabetes-related complications were recorded in 43 patients, the most common being autonomic neuropathy, retinopathy and nephropathy. The most frequently reported comorbidities were weight loss (72 patients), impotence (60 patients), hypertension (23 patients) and coronary artery disease (22 patients). Conclusions The present study describes the characteristics of patients with co-existent diabetic peripheral neuropathy and depression, aiming for prompt detection, prevention of further deterioration and improvement of patient outcomes. Available evidence shows that the majority of these patients are adults, with painful peripheral neuropathy and with insulin-treated and inadequately controlled diabetes. |
| Databáze: | OpenAIRE |
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