Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions
| Autor: | Andreas Håkansson, Javier A. Linares-Pastén, Atma-Sol Bustos, Lennart Nilsson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
biology sequestering mechanism Flavonoid myricetin aggregates lcsh:Chemical technology Article Colloid chemistry.chemical_compound Enzyme Monomer Molecular level chemistry Biochemistry biology.protein Myricetin lcsh:TP1-1185 Lipase intestinal conditions Beneficial effects lipase inhibition |
| Zdroj: | Foods, Vol 9, Iss 777, p 777 (2020) Foods |
| ISSN: | 2304-8158 |
| Popis: | Myricetin, a flavonoid found in the plant kingdom, has previously been identified as a food molecule with beneficial effects against obesity. This property has been related with its potential to inhibit lipase, the enzyme responsible of fat digestion. In this study we investigate the interaction between myricetin and lipase under simplified intestinal conditions from a colloidal point of view. The results show that myricetin form aggregates in aqueous medium and under simplified intestinal condition, where it was found that lipase is in its monomeric form. Although lipase inhibition by myricetin at a molecular level has been reported previously, the results of this study suggest that myricetin aggregates inhibit lipase by a sequestering mechanism as well. The size of these aggregates was determined to be in the range of a few nm to >200 nm. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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