New Polymorph Form of Dexamethasone Acetate
| Autor: | Mateus Felipe Schuchter Ambrósio, Maria Clara R. Freitas, Eugenio K. Epprecht, Daniel L. M. Aguiar, Lorenzo do Canto Visentin, Luciana A. Piovesan, Rosane A. S. San Gil, Bruno A. C. Horta, Ronaldo Pedro da Silva |
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| Rok vydání: | 2018 |
| Předmět: |
Diffraction
Magnetic Resonance Spectroscopy Materials science Molecular model Hydrogen bond Water Pharmaceutical Science Infrared spectroscopy Hydrogen Bonding 02 engineering and technology Crystal structure Crystallography X-Ray 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Dexamethasone 0104 chemical sciences Crystallography X-Ray Diffraction Solid-state nuclear magnetic resonance Molecule Crystallization 0210 nano-technology Single crystal |
| Zdroj: | Journal of Pharmaceutical Sciences. 107:672-681 |
| ISSN: | 0022-3549 |
| Popis: | A new monohydrated polymorph of dexamethasone acetate was crystallized and its crystal structure characterized. The different analytical techniques used for describing its structural and vibrational properties were: single crystal and polycrystal X-ray diffraction, solid state nuclear magnetic resonance, infrared spectroscopy. A Hirshfeld surface analysis was carried out through self-arrangement cemented by H-bonds observed in this new polymorph. This new polymorph form appeared because of self-arrangement via classical hydrogen bonds around the water molecule. |
| Databáze: | OpenAIRE |
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