Effect of antibiotic use for acute bronchiolitis on new-onset asthma in children
Autor: | Ting-Yi Wu, Hsin-Yi Huang, Hsin-Chun Huang, Wei-Ju Yeh, Jau-Ling Suen, I-Lun Chen, Chih-Hsing Hung, Yu-Han Chang, San-Nan Yang |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Male
medicine.medical_specialty medicine.drug_class Antibiotics Taiwan lcsh:Medicine Azithromycin Article Atopy 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Bronchodilator Odds Ratio medicine Humans 030212 general & internal medicine lcsh:Science Asthma Multidisciplinary business.industry lcsh:R Age Factors Odds ratio medicine.disease Confidence interval Anti-Bacterial Agents 030228 respiratory system Bronchiolitis Child Preschool Acute Disease Female lcsh:Q Macrolides business medicine.drug |
Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Early-life use of antibiotics is associated with asthma. We examined the effect of antibiotic use for early-life bronchiolitis on the development of new-onset asthma in children from Taiwan between 2005 and 2010. Data were from the National Health Insurance Research Database 2010, and diseases were coded using the International Classification of Disease (ICD). We classified the patients, all of whom had bronchiolitis, as having asthma or not having asthma. Asthma was diagnosed using ICD criteria and by use of an inhaled bronchodilator and/or corticosteroid twice in one year. We identified age at asthma onset, sex, residential area, history of atopy and NSAID use, age at first use of antibiotics, and the specific antibiotic, and adjusted for these factors using conditional logistic regression analysis. Among all individuals, there was a relationship between risk of new-onset asthma with use of a high dose of an antibiotic (adjusted odds ratio [aOR] = 3.33, 95% confidence interval [CI] = 2.67–4.15). Among the different antibiotics, macrolides (aOR = 2.87, 95% CI = 1.99–4.16), and azithromycin specifically (aOR = 3.45, 95% CI = 1.62–7.36), had the greatest effect of development of asthma. |
Databáze: | OpenAIRE |
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