Effects of phosphodiesterase-5 inhibition by sildenafil in the pressure overloaded right heart
| Autor: | Jens Erik Nielsen-Kudsk, Jan M. Nielsen, Uffe K. Schou, Asger Andersen, Erik Sloth, Christian Daugaard Peters |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Phosphodiesterase Inhibitors Sildenafil Hypertension Pulmonary Left ventricular hypertrophy Piperazines Sildenafil Citrate Muscle hypertrophy chemistry.chemical_compound Right ventricular hypertrophy Internal medicine medicine Animals Sulfones Rats Wistar Cyclic GMP Cyclic Nucleotide Phosphodiesterases Type 5 Pressure overload Hypertrophy Right Ventricular business.industry Phosphodiesterase 5 Inhibitors medicine.disease Pulmonary hypertension Rats medicine.anatomical_structure chemistry Echocardiography Purines Ventricle Heart failure Ventricular Function Right cardiovascular system Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Andersen, A, Nielsen, J M, Peters, C D, Schou, U K, Sloth, E & Nielsen-Kudsk, J E 2008, ' Effects of phosphodiesterase-5 inhibition by sildenafil in the pressure overloaded right heart ', European Journal of Heart Failure, vol. 10, no. 12, pp. 1158-1165 . https://doi.org/10.1016/j.ejheart.2008.09.016 |
| DOI: | 10.1016/j.ejheart.2008.09.016 |
| Popis: | Background: Sustained pressure overload of the right ventricle (RV) causes RV hypertrophy and failure. Cyclic-GMP has previously been shown to modulate left ventricular hypertrophy. Aim: To evaluate the effects of sildenafil, a phosphodiesterase-5 (PDE5) inhibitor elevating c-GMP, on myocardial hypertrophy and function in rats with RV hypertrophy. Methods: Rats were pulmonary trunk banded (PTB) and randomized to receive sildenafil (SIL) or vehicle (VEC) for three (n = 14) and nine weeks (n = 18). In addition, rats with established RV hypertrophy were randomized to SIL or VEC (n = 17) three weeks after PTB. Right ventricular function was evaluated by echocardiography and RV hypertrophy by histology and RV weight. Results: Sildenafil failed to inhibit the development of RV hypertrophy when given for both 3 and 9 weeks. On the contrary, sildenafil increased RV hypertrophy after 3 weeks (RV/bodyweight: SIL 0.099±0.016 vs. VEC 0.081±0.011; p |
| Databáze: | OpenAIRE |
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