Relation of BAALC and ERG Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases
| Autor: | Maha A El Taweel, Dalia Y Kadry, Thoreya Abd El Hameed, Reham A Rashed, Nahed Abd El Wahab |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Pathology Aging Myeloid genetic structures Epidemiology Bone Marrow Cells Biology Immunophenotyping Transcriptional Regulator ERG Bone Marrow Internal medicine medicine Biomarkers Tumor Humans BAALC Acute leukemia Gene Expression Profiling Public Health Environmental and Occupational Health Myeloid leukemia Middle Aged medicine.disease Neoplasm Proteins Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Treatment Outcome Disease Progression Trans-Activators Egypt Female Erg |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 16(17) |
| ISSN: | 2476-762X |
| Popis: | BACKGROUND The objectives of this study were to evaluate the expression of brain and acute leukemia, cytoplasmic (BAALC) gene and erythroblast transformation-specific related gene (ERG) in de novo cases of acute myeloid leukemia (AML) and identify roles in disease progression and outcome. MATERIALS AND METHODS This study included 50 newly diagnosed AML patients, along with 10 apparently healthy normal controls. BAALC and ERG expression was detected in the bone marrow of both patients and controls using real-time RT-PCR. RESULTS BAALC and ERG expression was detected in 52% of cases but not in any controls. There was a statistically significant correlation between BAALC and ERG gene expression and age (p- value=0.004 and 0.019, respectively). No statistical significance was noted for sex, lymphadenopathy, hepatomegaly, splenomegaly, other hematological findings, immunophenotyping and FAB sub-classification except for ERG gene and FAB (p-value=0.058). A statistical significant correlation was found between response to treatment with ERG expression (p-value=0.028) and age (p-value=0.014). A statistically significant variation in overall survival was evident with patient age, BM blast cells, FAB subgroups, BAALC and ERG expression (p-value= |
| Databáze: | OpenAIRE |
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