Longitudinal association between body mass index and health-related quality of life
| Autor: | Frank Sonntag, Rebecca Muckelbauer, Hendrike Berger, Stefan N. Willich, Karl Wegscheider, Ulrike Grittner, Heike Englert, Jacqueline Müller-Nordhorn, Heinz Völler, Hugo A. Katus, Christof Prugger |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Gerontology
Male Cross-sectional study Physiology lcsh:Medicine Body Mass Index Quality of life Weight loss Risk Factors Medicine and Health Sciences Longitudinal Studies Rosuvastatin Calcium lcsh:Science Sulfonamides Multidisciplinary Middle Aged humanities Physiological Parameters Cardiovascular Diseases Research Design Physical Sciences Female medicine.symptom Statistics (Mathematics) Research Article medicine.medical_specialty Clinical Research Design Hypercholesterolemia Cardiology Biostatistics Research and Analysis Methods Diabetes mellitus Mental Health and Psychiatry medicine Department Sport- und Gesundheitswissenschaften Humans Obesity Association (psychology) Aged Nutrition Health Care Policy Survey Research business.industry Body Weight lcsh:R Biology and Life Sciences medicine.disease Surgery Fluorobenzenes Health Care Cross-Sectional Studies Pyrimidines Quality of Life lcsh:Q Hydroxymethylglutaryl-CoA Reductase Inhibitors business Weight gain Body mass index Mathematics |
| Zdroj: | PLoS ONE, Vol 9, Iss 3, p e93071 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Objective Health-related quality of life (HRQoL) is an important outcome in individuals with a high risk for cardiovascular diseases. We investigated the association of HRQoL and body mass index (BMI) as an indicator for obesity. Design Secondary longitudinal analysis of the ORBITAL study, an intervention study which included high-risk cardiovascular primary care patients with hypercholesterolemia and an indication for statin therapy. Methods HRQoL was determined with the generic Short Form (SF)-12 health status instrument. Body weight and height were assessed at baseline and at months 6, 12, 18, 24, 30, and 36. We used a linear and a linear mixed-effects regression model to investigate the association between BMI and SF-12 summary scores at baseline as well as between change in BMI and SF-12 summary scores over 3 years. We adjusted for age, sex, smoking status, and in the longitudinal analysis also for the study arm and its interaction term with time. Results Of the 7640 participants who completed the baseline questionnaire, 6726 participants (mean age: 61 years) were analyzed. The baseline BMI was inversely associated with physical and mental SF-12 summary scores (β [95% CI] per 1 kg/m2: −0.36 [−0.41; −0.30] and −0.05 [−0.11; −0.00], respectively). A significant association between the change in BMI and physical SF-12 summary scores over time was only present in women (−0.18 [−0.27; −0.09]) and only in obese participants (−0.19 [−0.29; −0.10]). A change in BMI was directly associated with mental SF-12 summary scores (0.12 [0.06; 0.19]) in the total population. Conclusion Increases in BMI were associated with decreases in physical HRQoL, particularly in obese individuals and in women. In contrast, the mental HRQoL seemed to increase with increasing BMI over time. Thus, body weight management with respect to the HRQoL should be evaluated differentially by sex and body weight status. Trial Registration ClinicalTrials.gov NCT00379249 |
| Databáze: | OpenAIRE |
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