Engineered ECM Models: Opportunities to Advance Understanding of Tumor Heterogeneity
| Autor: | Claudia Fischbach, Adrian A. Shimpi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Prognostic factor Cell phenotype Cancer Tumor cells Cell Biology Computational biology Biology medicine.disease Phenotype Tumor heterogeneity Models Biological Article Extracellular Matrix Extracellular matrix 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Neoplastic Stem Cells Tumor Microenvironment Humans 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Curr Opin Cell Biol |
| Popis: | Intratumoral heterogeneity is a negative prognostic factor for cancer and commonly attributed to microenvironment-driven genetic mutations and/or the emergence of cancer stem-like cells. How aberrant extracellular matrix (ECM) remodeling regulates the phenotypic diversity of tumor cells, however, remains poorly understood due in part to a lack of model systems that allow isolating the physicochemical heterogeneity of malignancy-associated ECM for mechanistic studies. Here, we review the compositional, microarchitectural, and mechanical hallmarks of cancer-associated ECM and highlight biomaterials and engineering approaches to recapitulate these properties for in vitro and in vivo studies. Subsequently, we describe how such engineered platforms may be explored to define the spatiotemporal dynamics through which cancer-associated ECM remodeling regulates intratumoral heterogeneity and the cancer stem-like cell phenotype. Finally, we highlight future opportunities and technological advances to further elucidate the relationship between tumor-associated ECM dynamics and intratumoral heterogeneity. |
| Databáze: | OpenAIRE |
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