Serum and milk concentrations of apramycin in lactating cows, ewes and goats
| Autor: | R. Risenberg, A. Glickman, B. Kurtz, G. Ziv |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cmax
Sheep Diseases Mastitis Biology Apramycin Injections Intramuscular Limited access Absorption rate fluids and secretions Animal science Mammary Glands Animal Species Specificity Injection site medicine Animals Lactation Nebramycin Mastitis Bovine Pharmacology Volume of distribution Sheep General Veterinary Goats food and beverages medicine.disease Bioavailability Anti-Bacterial Agents Milk Injections Intravenous Linear Models Cattle Female medicine.drug |
| Zdroj: | Journal of veterinary pharmacology and therapeutics. 18(5) |
| ISSN: | 0140-7783 |
| Popis: | A 20% solution of apramycin was administered intravenously (i.v.) and intramuscularly (i.m.) to lactating cows with clinically normal and acutely inflamed udders, to lactating ewes with normal or subclinically infected, inflamed udders and i.v. to lactating goats with normal udders. The i.v. disposition kinetics of apramycin was very similar in cows, ewes and goats. The elimination half-life was approximately 2 h and the steady-state volume of distribution was 1.26-1.45 L/kg. The absorption rate of the drug from the i.m. injection site was rapid, the i.m. bioavailability was 60-70% and the mean elimination half-life was 265 min in cows and 145.5 min in ewes. The binding percentage of apramycin to serum protein was low (< 22.5%). Concentrations of apramycin in milk produced by clinically normal mammary glands of cows, ewes and goats were consistently lower than in serum; the kinetic value AUCmilk/AUCserum was < 0.32. Drug penetration into the milk from the acutely inflamed quarters of cows was extensive; mastitis milk Cmax values were more than tenfold greater than the Cmax in normal milk. On the other hand, the drug had limited access to the milk produced by subclinically infected inflamed half-udders of ewes. |
| Databáze: | OpenAIRE |
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