Autor: |
Matteo Brindisi, Manuela Curcio, Luca Frattaruolo, Giuseppe Cirillo, Antonella Leggio, Vittoria Rago, Fiore Pasquale Nicoletta, Anna Rita Cappello, Francesca Iemma |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
International Journal of Biological Macromolecules. 221:1491-1503 |
ISSN: |
0141-8130 |
Popis: |
DOX-loaded nanoparticles able to actively target CD44-receptors and respond to redox stimuli were proposed as non-conventional chemotherapeutic strategy in breast cancer. A covalent conjugate of human serum albumin and hyaluronic acid was prepared and assembled by a GSH-mediated desolvation in disulfide-crosslinked solid nanoparticles with mean diameter of 120 nm ± 3.4. The effective internalization of nanoparticles in cancer cells via CD44-receptors, together with the more efficient intracellular release, resulted in a significant increase of drug efficacy, with IC |
Databáze: |
OpenAIRE |
Externí odkaz: |
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