CD44-targeted nanoparticles with GSH-responsive activity as powerful therapeutic agents against breast cancer

Autor:	Matteo Brindisi, Manuela Curcio, Luca Frattaruolo, Giuseppe Cirillo, Antonella Leggio, Vittoria Rago, Fiore Pasquale Nicoletta, Anna Rita Cappello, Francesca Iemma
Rok vydání:	2022
Předmět:	Hyaluronan Receptors Doxorubicin Structural Biology Cell Line Tumor Humans Nanoparticles Female Breast Neoplasms General Medicine Hyaluronic Acid Molecular Biology Biochemistry
Zdroj:	International Journal of Biological Macromolecules. 221:1491-1503
ISSN:	0141-8130
Popis:	DOX-loaded nanoparticles able to actively target CD44-receptors and respond to redox stimuli were proposed as non-conventional chemotherapeutic strategy in breast cancer. A covalent conjugate of human serum albumin and hyaluronic acid was prepared and assembled by a GSH-mediated desolvation in disulfide-crosslinked solid nanoparticles with mean diameter of 120 nm ± 3.4. The effective internalization of nanoparticles in cancer cells via CD44-receptors, together with the more efficient intracellular release, resulted in a significant increase of drug efficacy, with IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747e0b391c9ebf14dd74894eef45ca33 https://doi.org/10.1016/j.ijbiomac.2022.09.157 Zobrazit plný text záznamu Full Text from ScienceDirect