Synthesis of β-substituted tryptamines by regioselective ring opening of aziridines
Autor: | Jeremy B. Morgan, Jesse B. Kidd, Kristen Maiden |
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Rok vydání: | 2016 |
Předmět: |
Indole test
Tryptamine 010405 organic chemistry Chemistry Stereochemistry Site selectivity Organic Chemistry Regioselectivity Aziridine 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Small molecule Article 0104 chemical sciences Tryptamines chemistry.chemical_compound Drug Discovery |
Zdroj: | Tetrahedron. 72(26) |
ISSN: | 0040-4020 |
Popis: | Functionalized tryptamines are targets of interest for development as small molecule therapeutics. The ring opening of aziridines with indoles is a powerful method for tryptamine synthesis if site selectivity can be controlled. 4-Nitrobenzyl carbamate (PNZ)-protected aziridines undergo regioselective ring opening to produce β-substituted tryptamines for a series of indoles. The PNZ-protected tryptamines can be further manipulated by PNZ removal under mild conditions. |
Databáze: | OpenAIRE |
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