Synthesis of β-substituted tryptamines by regioselective ring opening of aziridines

Autor: Jeremy B. Morgan, Jesse B. Kidd, Kristen Maiden
Rok vydání: 2016
Předmět:
Zdroj: Tetrahedron. 72(26)
ISSN: 0040-4020
Popis: Functionalized tryptamines are targets of interest for development as small molecule therapeutics. The ring opening of aziridines with indoles is a powerful method for tryptamine synthesis if site selectivity can be controlled. 4-Nitrobenzyl carbamate (PNZ)-protected aziridines undergo regioselective ring opening to produce β-substituted tryptamines for a series of indoles. The PNZ-protected tryptamines can be further manipulated by PNZ removal under mild conditions.
Databáze: OpenAIRE
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