Combined effects of chronic hyperglycaemia and oral aluminium intoxication on testicular tissue and some male reproductive parameters in Wistar rats
| Autor: | O. G. Adedeji, Oluwole B. Akinola, O. M. Olawoyin, T. A. Adelabu, S. A. Biliaminu, B. S. Oluwaseun |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male endocrine system medicine.medical_specialty endocrine system diseases Urology Motility Administration Oral Biology Hazardous Substances Streptozocin Diabetes Mellitus Experimental Lesion 03 medical and health sciences Follicle-stimulating hormone 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Testis medicine Animals Testosterone Rats Wistar Sperm motility 030219 obstetrics & reproductive medicine Estradiol Sperm Count Reproduction General Medicine medicine.disease Streptozotocin Rats 030104 developmental biology Hyperglycemia Toxicity Chronic Disease Sperm Motility medicine.symptom Follicle Stimulating Hormone medicine.drug Aluminum |
| Zdroj: | Andrologia. 48(7) |
| ISSN: | 1439-0272 |
| Popis: | Exposure to either environmental toxicants or chronic hyperglycaemia could impair male reproductive function. However, the extent to which exposure to such toxicants, in the presence of pre-existing metabolic dysfunction, could affect male reproduction is unclear. Streptozotocin-induced diabetic Wistar rats (12 weeks old) were exposed to oral aluminium chloride at 250 ppm for 30 days; followed by evaluation of caudal epididymal sperm count and motility, assay for serum follicle stimulating hormone (FSH), testosterone (T) and oestradiol; and assessment of testicular histology. Moreover, blood glucose was evaluated by the glucose oxidase method. In rats treated with streptozotocin (STZ) or aluminium (Al) alone, erosion of testicular parenchyma and stroma was observed. This effect was most severe in diabetic rats simultaneously exposed to Al; coupled with reduced caudal epididymal sperm count that was least in this (STZ+Al) group (18.75 × 10(6) ml(-1) ) compared with controls (61.25 × 10(6) ml(-1) ; P |
| Databáze: | OpenAIRE |
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