Effect of drug-coated balloon angioplasty on in-stent restenotic coronary lesions analyzed with optical coherence tomography and serial coronary artery angioscopy
Autor: | Hidesato Fujito, Korehito Iida, Yasunari Ebuchi, Daisuke Kitano, Takashi Mineki, Yutaka Koyama, Tomoyuki Morikawa, Nobuhiro Murata, Atsushi Hirayama, Keisuke Kojima, Yasuo Okumura, Takafumi Hiro, Takaaki Kougo, Tadateru Takayama, Hironori Haruta, Suguru Migita, Naotaka Akutsu, Toru Oshima, Mitsumasa Sudo, Daisuke Fukamachi, Toshihiko Nishida, Takehiro Tamaki, Akihito Ogaku |
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Rok vydání: | 2019 |
Předmět: |
Male
Reoperation Neointima medicine.medical_specialty medicine.medical_treatment Angioscopy 030204 cardiovascular system & hematology Coronary Angiography Balloon Coronary Restenosis 03 medical and health sciences 0302 clinical medicine Coated Materials Biocompatible Restenosis Angioplasty medicine Humans 030212 general & internal medicine Angioplasty Balloon Coronary Aged Retrospective Studies medicine.diagnostic_test business.industry Graft Occlusion Vascular Stent Drug-Eluting Stents medicine.disease Coronary Vessels Cardiac surgery medicine.anatomical_structure Female Cardiology and Cardiovascular Medicine business Nuclear medicine Tomography Optical Coherence Follow-Up Studies Artery |
Zdroj: | Heart and Vessels. 34:1925-1935 |
ISSN: | 1615-2573 0910-8327 |
DOI: | 10.1007/s00380-019-01447-5 |
Popis: | Drug-coated balloon angioplasty (DCBA) has been recognized for its utility in preventing in-stent re-restenosis (ISR); however, imaging of the neointima immediately after treatment and during follow-up has only been described in a few case reports. This study aimed to determine the efficacy and mechanism of the DCBA using imaging studies both immediately after the DCBA and during the follow-up period. We enrolled 15 consecutive patients who underwent DCBA for in-stent restenosis (ISR). The in-stent neointimal volume was evaluated using optical coherence tomography (OCT), and the in-stent yellow grade was assessed using coronary angioscopy (CAS) immediately after DCBA and during the median follow-up period of 9 (8–15) months. The neointimal volume was significantly reduced from 77.1 ± 36.2 mm3 at baseline to 60.2 ± 23.9 mm3 immediately after DCBA (p = 0.0012 vs. baseline) and to 46.7 ± 21.9 mm3 during the follow-up (p = 0.0002 vs. post DCBA). The yellow grade of the residual plaques at the ISR lesion, which indicated plaque vulnerability, was significantly decreased in the follow-up CAG (from baseline: 1.79 ± 1.03, during the follow-up: 0.76 ± 0.82; p |
Databáze: | OpenAIRE |
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