Effect of drug-coated balloon angioplasty on in-stent restenotic coronary lesions analyzed with optical coherence tomography and serial coronary artery angioscopy

Autor: Hidesato Fujito, Korehito Iida, Yasunari Ebuchi, Daisuke Kitano, Takashi Mineki, Yutaka Koyama, Tomoyuki Morikawa, Nobuhiro Murata, Atsushi Hirayama, Keisuke Kojima, Yasuo Okumura, Takafumi Hiro, Takaaki Kougo, Tadateru Takayama, Hironori Haruta, Suguru Migita, Naotaka Akutsu, Toru Oshima, Mitsumasa Sudo, Daisuke Fukamachi, Toshihiko Nishida, Takehiro Tamaki, Akihito Ogaku
Rok vydání: 2019
Předmět:
Zdroj: Heart and Vessels. 34:1925-1935
ISSN: 1615-2573
0910-8327
DOI: 10.1007/s00380-019-01447-5
Popis: Drug-coated balloon angioplasty (DCBA) has been recognized for its utility in preventing in-stent re-restenosis (ISR); however, imaging of the neointima immediately after treatment and during follow-up has only been described in a few case reports. This study aimed to determine the efficacy and mechanism of the DCBA using imaging studies both immediately after the DCBA and during the follow-up period. We enrolled 15 consecutive patients who underwent DCBA for in-stent restenosis (ISR). The in-stent neointimal volume was evaluated using optical coherence tomography (OCT), and the in-stent yellow grade was assessed using coronary angioscopy (CAS) immediately after DCBA and during the median follow-up period of 9 (8–15) months. The neointimal volume was significantly reduced from 77.1 ± 36.2 mm3 at baseline to 60.2 ± 23.9 mm3 immediately after DCBA (p = 0.0012 vs. baseline) and to 46.7 ± 21.9 mm3 during the follow-up (p = 0.0002 vs. post DCBA). The yellow grade of the residual plaques at the ISR lesion, which indicated plaque vulnerability, was significantly decreased in the follow-up CAG (from baseline: 1.79 ± 1.03, during the follow-up: 0.76 ± 0.82; p
Databáze: OpenAIRE
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