Synthesis of pH stable, blue light-emitting diode-excited, fluorescent silica nanoparticles and effects on cell behavior
| Autor: | George R. Beck, Jin-Kyu Lee, Shin-Woo Ha |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Biocompatibility Silicon dioxide Biophysics Pharmaceutical Science Nanoparticle Quantum yield Bone Marrow Cells Bioengineering Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials Mice chemistry.chemical_compound International Journal of Nanomedicine Drug Discovery Animals Particle Size health care economics and organizations Original Research Fluorescent Dyes Diode reduced toxicity Organic Chemistry technology industry and agriculture imaging General Medicine Hydrogen-Ion Concentration respiratory system Silicon Dioxide 021001 nanoscience & nanotechnology naphthalimide Fluorescence humanities 0104 chemical sciences 3. Good health Naphthalimides chemistry bone marrow stromal cell migration Excited state Nanoparticles Particle size 0210 nano-technology |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 |
| DOI: | 10.2147/ijn.s139562 |
| Popis: | Shin-Woo Ha,1 Jin-Kyu Lee,2 George R Beck Jr1,3,4 1Division of Endocrinology, Department of Medicine, Emory University, Atlanta, GA, USA; 2Department of Chemistry, Seoul National University, Seoul, South Korea; 3The Atlanta Department of Veterans Affairs Medical Center, Decatur, 4The Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA Abstract: To date, delivery of light-emitting diode (LED)-activated compounds to cells and tissue remains a challenge. Silica-based materials possess good biocompatibility and have advantages of control of size and shape. Fluorescent silica nanoparticles (NPs) have been synthesized and used for applications such as cell tracking and tumor identification. Here, we report the synthesis and optimization of fluorescent silica NPs, which incorporate a naphthalimide dye with triethoxysilanes that are excited by the blue LED wavelength (LEDex NPs). The NPs can be imaged in the 420–470nm wavelength, demonstrate a high quantum yield, are stable in a range of pH, and are taken into the cells. Therefore, these NPs represent a novel imaging technology for biomedical applications. Keywords: naphthalimide, imaging, bone marrow stromal cell migration, reduced toxicity |
| Databáze: | OpenAIRE |
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