Gene–gene interaction between interleukin-6 and interleukin-10 reduces AD risk
| Autor: | Onofre Combarros, J. L. Fernández-Luna, Javier Llorca, José Berciano, C. Sanz, Jon Infante |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Risk medicine.medical_specialty Genotype medicine.medical_treatment White People Apolipoproteins E Gene Frequency Gene interaction Alzheimer Disease Internal medicine medicine Humans Genetic Predisposition to Disease Interleukin 6 Alleles Aged Sequence Deletion Aged 80 and over Inflammation Regulation of gene expression Polymorphism Genetic biology Microglia Interleukin-6 business.industry Neurodegeneration Epistasis Genetic Middle Aged medicine.disease Interleukin-10 Interleukin 10 Endocrinology medicine.anatomical_structure Cytokine Gene Expression Regulation Spain Immunology biology.protein Female Neurology (clinical) Alzheimer's disease business |
| Zdroj: | Neurology. 63:1135-1136 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/01.wnl.0000138570.96291.a8 |
| Popis: | A chronic inflammatory process might contribute to the neurodegeneration associated with Alzheimer disease (AD), through overexpression of cytokines and other inflammatory molecules in activated microglia surrounding senile plaques.1 The balance between pro- and anti-inflammatory cytokines determines the magnitude of this inflammatory response. As demonstrated by the whole-blood stimulation assay with endotoxin, patients with AD produce relatively more pro-inflammatory interleukin-6 (IL-6) and less anti-inflammatory IL-10 as compared with control subjects without dementia.1 There is evidence that the cytokine response as measured in a whole-blood assay might reflect similar effects across the blood–brain barrier.1 The (−174) IL-6 and (−1,082) IL-10 gene promoter polymorphisms have been shown to influence the susceptibility to AD, by regulating transcription rates and blood levels of these cytokines, but the relevance of the IL-62,3⇓ and IL-104,5⇓ genes in AD remains controversial. We investigated whether the combined genetic effects between IL-6 and IL-10 polymorphisms might be responsible, at least in part, for susceptibility to AD. The study included 232 AD patients (67% women; mean age at the … |
| Databáze: | OpenAIRE |
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