Peripheral levels of superoxide dismutase and glutathione peroxidase in youths in ultra-high risk for psychosis: a pilot study
| Autor: | Rodrigo B. Mansur, Elson Asevedo, Maiara Zeni-Graiff, Lucas B. Rizzo, Pedro Mario Pan, Rodrigo A. Bressan, Graccielle R. Cunha, Ana S. Yamagata, Elisa Brietzke, Sumit Sethi, Adiel C. Rios, Pawan Kumar Maurya, André Zugman, Ary Gadelha |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Adolescent Global Assessment of Functioning Rate ratio medicine.disease_cause Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans chemistry.chemical_classification First episode Glutathione Peroxidase biology business.industry Superoxide Dismutase Glutathione peroxidase medicine.disease 030227 psychiatry Psychiatry and Mental health chemistry Psychotic Disorders Schizophrenia Case-Control Studies biology.protein Female Neurology (clinical) Disease Susceptibility business 030217 neurology & neurosurgery Oxidative stress Biomarkers |
| Zdroj: | CNS spectrums. 24(3) |
| ISSN: | 1092-8529 |
| Popis: | IntroductionOxidative stress has been documented in chronic schizophrenia and in the first episode of psychosis, but there are very little data on oxidative stress prior to the disease onset.ObjectiveThis work aimed to compare serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in young individuals at ultra-high risk (UHR) of developing psychosis with a comparison healthy control group (HC).MethodsThirteen UHR subjects and 29 age- and sex-matched healthy controls (HC) were enrolled in this study. Clinical assessment included the Comprehensive Assessment of At-Risk Mental States (CAARMS), the Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I) or the Kiddie-SADS-Present and Lifetime Version (K-SADS-PL), and the Global Assessment of Functioning (GAF) scale. Activities of SOD and GPx were measured in serum by the spectrophotometric method using enzyme-linked immunosorbent assay kits.ResultsAfter adjusting for age and years of education, there was a significant lower activity of SOD and lower GPX activity in the UHR group compared to the healthy control group (rate ratio [RR]=0.330, 95% CI 0.187; 0.584, pConclusionOur results suggest that oxidative imbalances could be present prior to the onset of full-blown psychosis, including in at-risk stages. Future studies should replicate and expand these results. |
| Databáze: | OpenAIRE |
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