A three-dimensional chemo-mechanical continuum model for smooth muscle contraction
| Autor: | André Schmitz, Markus Böl, Götz Nowak, Tobias Siebert |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Swine Finite Element Analysis Biomedical Engineering Calcium diffusion Strain energy Biomaterials Smooth muscle medicine Animals Mechanical Phenomena Physics Chemo mechanical Muscle Smooth Anatomy Smooth muscle contraction Mechanics Finite element method Biomechanical Phenomena Carotid Arteries Vasoconstriction Mechanics of Materials Calcium concentration Calcium Stress Mechanical medicine.symptom Muscle Contraction Muscle contraction |
| Zdroj: | Journal of the Mechanical Behavior of Biomedical Materials. 13:215-229 |
| ISSN: | 1751-6161 |
| DOI: | 10.1016/j.jmbbm.2012.05.015 |
| Popis: | Based on two fields, namely the placement and the calcium concentration, a chemo-mechanically coupled three-dimensional model, describing the contractile behaviour of smooth muscles, is presented by means of a strain energy function. The strain energy function (Schmitz and Böl, 2011) is additively decomposed into a passive part, relating to elastin and collagen, and an active calcium-driven part related to the chemical contraction of the smooth muscle cells. For the description of the calcium phase the four state cross-bridge model of Hai and Murphy (Hai and Murphy, 1988) has been implemented into the finite element method. Beside three-dimensional illustrative boundary-value problems demonstrating the features of the presented modelling concept, simulations on an idealised artery document the applicability of the model to more realistic geometries. |
| Databáze: | OpenAIRE |
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