Increased secretion of brain natriuretic peptide and atrial natriuretic peptide, but not sufficient to induce natriuresis in rats with nephrotic syndrome
| Autor: | Naoto Yokota, Masahito Aburaya, Tanenao Eto, Naoto Minamino, Yamamoto Y, Kazuo Kitamura, Kenji Kangawa, Hisayuki Matsuo, Kenjiro Tanaka |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Nephrotic Syndrome Heart Ventricles Biophysics Natriuresis Nerve Tissue Proteins Peptide hormone Biochemistry Excretion Atrial natriuretic peptide Internal medicine Natriuretic Peptide Brain medicine Animals Heart Atria cardiovascular diseases Molecular Biology Chemistry Sodium Rats Inbred Strains Glomerulonephritis Cell Biology Brain natriuretic peptide medicine.disease Rats Endocrinology medicine.anatomical_structure Doxorubicin Ventricle cardiovascular system human activities Nephrotic syndrome Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology |
| Zdroj: | Biochemical and Biophysical Research Communications. 174:128-135 |
| ISSN: | 0006-291X |
| Popis: | The levels of immunoreactive brain natriuretic peptide (ir-BNP) and immunoreactive atrial natriuretic peptide (ir-ANP) were evaluated by radioimmunoassay in both the atrium, ventricle and plasma of adriamycin-induced nephrotic rats and control rats. There was no difference in right and left atrial concentrations of ir-BNP, however, a higher right atrial concentration of ir-ANP was observed in nephrotic rats than in controls (p less than 0.01). The ventricular ir-BNP and ir-ANP were increased in nephrotic rats compared to controls (BNP: p less than 0.001, ANP: p less than 0.001). Cardiac BNPs were composed of pro-BNP (gamma-BNP) and its C-terminal 45-amino-acid peptide (BNP-45). The ratio of BNP-45/gamma-BNP in nephrotic rats was higher than that of controls in both atria and in the ventricle. Plasma ir-BNP and ir-ANP were significantly higher in nephrotic rats than in controls (BNP: p less than 0.001, ANP: p less than 0.001), and each level was negatively correlated with urinary sodium excretion in nephrotic rats (BNP: r = -0.84, p less than 0.001, ANP: r = -0.88, p less than 0.001). These results suggest that production and secretion of both BNP and ANP are concomitantly stimulated by a decreased renal ability to eliminate sodium and water, but this secretion is insufficient to induce effective natriuresis in nephrotic rats. |
| Databáze: | OpenAIRE |
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