The effects of fenofibrate on metabolic and vascular changes induced by chocolate-supplemented diet in the rat
| Autor: | Sameer Fatani, Ebrahim K. Naderali |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Leptin
Male Nitroprusside medicine.medical_specialty Vasodilator Agents medicine.medical_treatment Fatty Acids Nonesterified In Vitro Techniques Biology Potassium Chloride Norepinephrine Random Allocation Fenofibrate Internal medicine medicine Animals Vasoconstrictor Agents Rats Wistar Endothelial dysfunction Mesenteric arteries Triglycerides Hypolipidemic Agents Pharmacology Cacao Dose-Response Relationship Drug Myocardium Insulin Body Weight Metabolism medicine.disease Mesenteric Arteries Rats Vasodilation Dose–response relationship Endocrinology medicine.anatomical_structure Hematocrit Vasoconstriction Dietary Supplements Carbachol Endothelium Vascular Sodium nitroprusside Energy Intake medicine.drug |
| Zdroj: | European Journal of Pharmacology. 521:99-104 |
| ISSN: | 0014-2999 |
| Popis: | Current evidences suggest that diet per se plays an important role in genesis of metabolic and vascular function abnormalities. We have investigated the effects of addition of a high-fat diet (chocolate) in the presence or absence of short-term (7 days) administration of fenofibrate on metabolic and vascular changes in adult male Wistar rats. Despite similarities in total body weight in all groups, compared with control fed groups, chocolate-supplemented animals had significantly higher plasma triacylglyceride and non-esterified fatty acids and leptin (for all, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect