Relationship between subarachnoid and central canal hemorrhage and spasticity: A first experimental study

Autor: Tayfun Cakir, Baris Ozoner, Selim Kayaci, Sare Sipal, Orhan Baş, Mehmet Dumlu Aydin
Rok vydání: 2019
Předmět:
Zdroj: J Spinal Cord Med
ISSN: 2045-7723
1079-0268
Popis: Objective: Spastic disorders are considered as important cerebral complications of subarachnoid hemorrhage (SAH). However, there has been no research concerning the pathophysiological mechanism of its link with the spinal cord. The present study aimed to assess the relationship between the development of spasticity and neuronal degeneration after SAH and increase in spinal cord pressure after central canal hemorrhage (CCH). Participants: Twenty-three rabbits were included. Outcome measures: Of all rabbits, 5, 5, and 13 were allocated in the control, SHAM and study groups, respectively. Moreover, 1 cc of saline and 1 cc of autologous arterial blood were injected into the cisterna magna of the SHAM and study groups, respectively. The Muscle spasticity tension values (MSTVs) were determined according to the modified Ashworth scale. Degenerated neuron densities (DND) in the gray matter (GM) of each animal's spinal cord were stereologically calculated. Results: The average MSTV of each group was as follows: control group (n = 5) 2; SHAM group (n = 5) 3-5; and study group (n = 13) 8–10. The DND values of the spinal cord of each group were as follows: control group, 2 ± 1/mm(3); SHAM group, 12 ± 3/mm(3); and study group, 34 ± 9/mm(3). Results showed an important linear relationship between the MSTVs and the DND of the spinal cord (P
Databáze: OpenAIRE