Association of early-onset diabetes, prediabetes and early glycaemic recovery with the risk of all-cause and cardiovascular mortality
| Autor: | Sin Gon Kim, Sang Min Park, Joung Sik Son, Yeon Yong Kim, Seung Sik Hwang, Sungmin Kim, Gyeongsil Lee, Seulggie Choi, Seong Yong Park, Kyuwoong Kim, Su Min Jeong, Jae-Moon Yun |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Prediabetic State Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus Internal medicine Diabetes Mellitus Internal Medicine medicine Humans Longitudinal Studies Prediabetes Myocardial infarction Young adult Stroke Disease burden business.industry Incidence Incidence (epidemiology) Fasting medicine.disease Impaired fasting glucose 030104 developmental biology Cardiovascular Diseases Female business |
| Zdroj: | Diabetologia. 63:2305-2314 |
| ISSN: | 1432-0428 0012-186X |
| Popis: | The increasing incidence of diabetes among young adults is a disease burden; however, the effects of early-onset diabetes, prediabetes and glycaemic recovery on CVD or mortality remain unclear. We aimed to investigate the association of these factors with 10 year all-cause mortality, CVD mortality and CVD incidence in Korean young adults.This large and longitudinal cohort study included data from the Korean National Health Insurance Service-National Health Information Database; 2,502,375 young adults aged 20-39 years without diabetes mellitus and CVD at baseline were included. Glycaemic status was measured twice, first in 2002-2003 and second in 2004-2005. Changes in fasting glucose levels were evaluated according to fasting glucose status: normal fasting glucose (NFG;5.5 mmol/l), impaired fasting glucose (IFG; 5.5-6.9 mmol/l), and diabetic fasting glucose (DFG; ≥7.0 mmol/l). Primary outcomes were all-cause and CVD mortality risk. The secondary outcome was incidence of CVD, including acute myocardial infarction and stroke. All outcomes arose from the 10 year follow-up period 1 Jan 2006 to 31 December 2015.Individuals with NFG at baseline, who were subsequently newly diagnosed with diabetes and prediabetes (IFG), had increased all-cause mortality (HR [95% CI] 1.60 [1.44, 1.78] and 1.13 [1.09, 1.18], respectively) and CVD incidence (1.13 [1.05, 1.23] and 1.04 [1.01, 1.07], respectively). In those with DFG at baseline, early recovery to NFG and IFG was associated with decreased all-cause mortality (0.57 [0.46, 0.70] and 0.65 [0.53, 0.81], respectively) and CVD incidence (0.70 [0.60, 0.81] and 0.78 [0.66, 0.91], respectively). Among patients with IFG at baseline, early recovery to NFG was associated with decreased CVD mortality (0.74 [0.59, 0.93]).Early-onset diabetes or prediabetes increased CVD risks and all-cause mortality after the 10 year follow-up. Furthermore, recovery of hyperglycaemia could reduce the subsequent 10 year risk for CVD incidence and all-cause mortality. Graphical abstract. |
| Databáze: | OpenAIRE |
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