Flavonoid Metabolites in Human Urine during Blueberry Anthocyanin Intake
| Autor: | Yan Liu, Sherry Fillmore, Wilhelmina Kalt, Jane E. McDonald |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Metabolite Blueberry Plants Flavonoid Urine Biology 01 natural sciences Anthocyanins Young Adult 03 medical and health sciences chemistry.chemical_compound Tandem Mass Spectrometry hemic and lymphatic diseases Humans Food science Chromatography High Pressure Liquid reproductive and urinary physiology Flavonoids chemistry.chemical_classification Gastrointestinal tract 030109 nutrition & dietetics Chromatography 010401 analytical chemistry food and beverages General Chemistry Middle Aged female genital diseases and pregnancy complications 0104 chemical sciences Bioavailability Aglycone chemistry Fruit Anthocyanin Female General Agricultural and Biological Sciences |
| Zdroj: | Journal of Agricultural and Food Chemistry. 65:1582-1591 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | The human health benefits of anthocyanins (Anc) and other flavonoids are widely recognized. However, the flavonoid-based urinary metabolites arising in vivo after Anc intake are not well described. Human (n = 17) urine was collected while blueberry juice (BJ) was consumed daily for 28 days and once after a 7 day washout. MS/MS scanning of 664 urine samples for 18 parent Anc (PAnc) and 42 predicted Anc metabolites (AncM) yielded 371 products (i.e., MS/MS × retention time (RT)). Flavonoid-based AncM, which were likely underestimated, were almost 20 times more abundant than PAnc. Together, PAnc and AncM accounted for about 1% of the daily Anc dose. Aglycone forms were >94% of the total. Cluster analysis of the 371 Anc identified about 55 major Anc that contributed about 80% to the total Anc. The abundance of flavonoid-based Anc-derived products in the gastrointestinal tract could contribute to the health benefits of Anc-rich berries. |
| Databáze: | OpenAIRE |
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