A sportomics strategy to analyze the ability of arginine to modulate both ammonia and lymphocyte levels in blood after high-intensity exercise
| Autor: | Joao Pedro Werneck-de-Castro, Luis Carlos Gonçalves, Artur Bessa, Ricardo Freitas-Dias, Luiz Claudio Cameron, Rafael Luzes, Adriana Bassini |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Arginine Lymphocyte lcsh:TX341-641 Clinical nutrition Placebo Internal medicine medicine lcsh:Sports medicine Immune response Nutrition and Dietetics business.industry Hyperammonemia Metabolism Short-duration exercise medicine.disease Glutamine medicine.anatomical_structure Endocrinology White blood cells Amino acids Analysis of variance lcsh:RC1200-1245 business lcsh:Nutrition. Foods and food supply Food Science Research Article Granulocytes |
| Zdroj: | Journal of the International Society of Sports Nutrition Journal of the International Society of Sports Nutrition, Vol 9, Iss 1, p 30 (2012) |
| ISSN: | 1550-2783 |
| Popis: | Background Exercise is an excellent tool to study the interactions between metabolic stress and the immune system. Specifically, high-intensity exercises both produce transient hyperammonemia and influence the distribution of white blood cells. Carbohydrates and glutamine and arginine supplementation were previously shown to effectively modulate ammonia levels during exercise. In this study, we used a short-duration, high-intensity exercise together with a low carbohydrate diet to induce a hyperammonemia state and better understand how arginine influences both ammonemia and the distribution of leukocytes in the blood. Methods Brazilian Jiu-Jitsu practitioners (men, n = 39) volunteered for this study. The subjects followed a low-carbohydrate diet for four days before the trials and received either arginine supplementation (100 mg·kg-1 of body mass·day-1) or a placebo. The intergroup statistical significance was calculated by a one-way analysis of variance, followed by Student’s t-test. The data correlations were calculated using Pearson’s test. Results In the control group, ammonemia increased during matches at almost twice the rate of the arginine group (25 mmol·L-1·min-1 and 13 μmol·L-1·min-1, respectively). Exercise induced an increase in leukocytes of approximately 75%. An even greater difference was observed in the lymphocyte count, which increased 2.2-fold in the control group; this increase was partially prevented by arginine supplementation. The shape of the ammonemia curve suggests that arginine helps prevent increases in ammonia levels. Conclusions These data indicate that increases in lymphocytes and ammonia are simultaneously reduced by arginine supplementation. We propose that increased serum lymphocytes could be related to changes in ammonemia and ammonia metabolism. |
| Databáze: | OpenAIRE |
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