Effects of the dopamine/norepinephrine releaser phenmetrazine on cocaine self-administration and cocaine-primed reinstatement in rats
| Autor: | Phuong Tran, Thomas J. Martin, Thomas J.R. Beveridge, Amanda Grigg, Paul W. Czoty, Leanne N. Thomas, Bruce E. Blough |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Dopamine Pharmacology toxicology Self Administration Cocaine related disorders Pharmacology Article Rats sprague dawley Rats Sprague-Dawley Norepinephrine (medication) Cocaine-Related Disorders Eating Norepinephrine Cocaine medicine Animals Phenmetrazine business.industry fungi food and beverages Macaca mulatta Rats Monoamine neurotransmitter Self-administration business Reinforcement Psychology medicine.drug |
| Zdroj: | Psychopharmacology. 232:2405-2414 |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | Like other monoamine releasers such as D-amphetamine, chronic treatment with phenmetrazine can attenuate cocaine self-administration in monkeys.The present studies extended this finding to rodents and to cocaine-primed reinstatement, a putative laboratory animal model of relapse.In experiment 1, rats self-administered food pellets or injections of 0.19 mg/kg cocaine (i.v.) under a progressive-ratio schedule. When responding was stable, subcutaneous osmotic pumps were implanted containing saline or (+)-phenmetrazine (25 or 50 mg/kg per day). In experiment 2, rats self-administered injections of 0.75 mg/kg cocaine under a fixed-ratio 1 schedule in daily 6-h sessions. When responding was stable, rats were removed from the self-administration environment for 7 days and treated continuously with saline, 5 mg/kg per day D-amphetamine or phenmetrazine (25 or 50 mg/kg per day) via osmotic pumps. Rats were then returned to the self-administration context while treatment continued, and responding was extinguished by removing response-contingent stimulus changes and cocaine injections. Once responding was extinguished, reinstatement tests were conducted using cocaine injections (10 mg/kg i.p.).Phenmetrazine decreased self-administration of cocaine, but not food pellets, during the 14-day treatment period; effects persisted for several days after treatment was discontinued. Moreover, cocaine-induced increases in responding during the reinstatement test were attenuated by D-amphetamine and both phenmetrazine doses.These results extend the study of the effects of phenmetrazine on cocaine self-administration to a rodent model, and provide further support for the use of monoamine releasers as agonist medications for cocaine abuse. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|