Long-term BMI change trajectories in Chinese adults and its association with the hazard of type 2 diabetes: evidence from a 20-year China Health and Nutrition Survey
| Autor: | Duolao Wang, Shaonong Dang, Wentao Wu, Jiaoyang Du, Yaling Zhao, Chenlu Wu, Baibing Mi, Xiangyu Gao, Hong Yan |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Research design China Longitudinal study wk_810 Endocrinology Diabetes and Metabolism Type 2 diabetes wk_20 Diseases of the endocrine glands. Clinical endocrinology Body Mass Index BMI Weight loss Diabetes mellitus Weight Loss Humans Medicine Epidemiology/Health Services Research wd_100 Chinese business.industry longitudinal study Regression analysis Nutrition Surveys medicine.disease RC648-665 Diabetes Mellitus Type 2 type 2 diabetes medicine.symptom business Body mass index Demography wb_200 |
| Zdroj: | BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020) BMJ Open Diabetes Research & Care |
| ISSN: | 2052-4897 |
| Popis: | IntroductionTo investigate the relationship between long-term change trajectory in body mass index (BMI) and the hazard of type 2 diabetes among Chinese adults.Research design and methodsData were obtained from the China Health and Nutrition Survey (CHNS). Type 2 diabetes was reported by participants themselves in each survey wave. The duration of follow-up was defined as the period from the first visit to the first time self-reported type 2 diabetes, death, or other loss to follow-up from CHNS. The patterns of change trajectories in BMI were derived by latent class trajectory analysis method. The Fine and Gray regression model was used to estimate HRs with corresponding 95% CIs for type 2 diabetes.ResultsFour patterns of the trajectories of change in BMI were identified among Chinese adults, 42.7% of participants had stable BMI change, 40.8% for moderate BMI gain, 8.9% for substantial BMI gain and 7.7% for weight loss. During the follow-up with mean 11.2 years (158 637 person-years contributed by 14 185 participants), 498 people with type 2 diabetes (3.7%) occurred. Risk of type 2 diabetes was increased by 47% among people who gained BMI more substantially and rapidly (HR: 1.47, 95% CI 1.08 to 2.02, p=0.016) and increased by 20% among those in people with the moderate BMI gain (HR: 1.20, 95% CI 0.98 to 1.48, p=0.078), compared with those with stable BMI change.ConclusionsLong-term substantial gain of BMI was significantly associated with an increased risk of type 2 diabetes in the Chinese adults. |
| Databáze: | OpenAIRE |
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