Effect of mouse nerve growth factor on the expression of glial fibrillary acidic protein in hippocampus of neonatal rats with hypoxic-ischemic brain damage
| Autor: | Wei Wei, Yannan Chai, Yu Wang, Zhichun Feng, Xiaojuan Yin, Lei Dong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology medicine.medical_treatment Brain damage Hippocampal formation neonatal rat Immunology and Microbiology (miscellaneous) Internal medicine medicine Hippocampus (mythology) Glial fibrillary acidic protein biology business.industry Growth factor Dentate gyrus General Medicine Articles Endocrinology nervous system Apoptosis hypoxic-ischemic brain damage glial fibrillary acidic protein biology.protein mouse nerve growth factor Immunohistochemistry medicine.symptom business |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | The present study aimed to investigate the influence of mouse nerve growth factor (mNGF) on glial fibrillary acidic protein (GFAP) expression in neonatal rats with hypoxic-ischemic brain damage (HIBD). A total of 60 7-day-old neonatal rats were randomly divided into control, HIBD and mNGF groups (n=20). The rats in the mNGF group were injected intramuscularly with mNGF once a day for 5 days. Each group was randomly divided into a day 7 subgroup and a day 14 subgroup according to the time of sacrifice. After the rats were sacrificed, the expression of GFAP in the hippocampus in the three groups was confirmed by immunohistochemical analysis. The results revealed that the expression level of GFAP in the ischemic side of the hippocampus in the mNGF and HIBD groups was higher compared with that in the control group at days 7 and 14 after surgery, respectively (P |
| Databáze: | OpenAIRE |
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