Higher b-values improve the correlation between diffusion MRI and the cortical microarchitecture
| Autor: | Vincent Dousset, N. Ichinose, V.H. Prevost, Sandy Mournet, Ismail Koubiyr, Bassem Hiba, H. Kusahara, Thomas Tourdias, G. Okubo, B. Triaire, B. Zhang |
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| Přispěvatelé: | Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2020 |
| Předmět: |
Surface map
Signal-To-Noise Ratio 030218 nuclear medicine & medical imaging Correlation 03 medical and health sciences Myelin [SPI]Engineering Sciences [physics] 0302 clinical medicine Nuclear magnetic resonance Healthy volunteers Linear regression Image Processing Computer-Assisted Medicine Humans Radiology Nuclear Medicine and imaging Cortical surface ComputingMilieux_MISCELLANEOUS Brain Mapping business.industry Brain Healthy Volunteers medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Kurtosis Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Neuroradiology Neuroradiology, Springer Verlag, 2020, 62 (11), pp.1411-1419. ⟨10.1007/s00234-020-02462-4⟩ |
| ISSN: | 1432-1920 0028-3940 |
| DOI: | 10.1007/s00234-020-02462-4⟩ |
| Popis: | In diffusion MRI (dMRI), it remains unclear to know how much increase of b-value is conveying additional biological meaning. We tested the correlations between cortical microarchitecture and diffusion metrics computed from standard (1000 s/mm2), high (3000 s/mm2), to very high (5000 s/mm2) b-value dMRI. Healthy volunteers were scanned with a dMRI pulse sequence that was first optimized together with a T1-WI and T2-WI. Averaged cortical surface map of estimated myelin (T1-WI/T2-WI) was compared with surface maps of mean diffusivity (MD) computed from each b-value (MD1000, MD3000, and MD5000) and to surface map of mean kurtosis (MK computed from the 0-, 1000-, to 3000-s/mm2 shells) in 360 cortical parcels using Spearman correlations, multiple linear regressions, and Akaike information criteria (AIC). Surface map from MD1000 showed variations not related to myelin but the MD3000 and MD5000 maps inversely mirrored estimated myelin map; lower MD values being observed in more myelinated cortical areas. MK mirrored myelinated cortical areas. Quantitatively, Spearman correlations between myelin and MD became more and more negative as long as b-values increased while the correlation was positive between myelin and MK. Multiple regression models confirmed negative associations between myelin and MD that were significantly better from MD1000 to MD3000 and MD5000 (R2 = 0.33, p |
| Databáze: | OpenAIRE |
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