Corneal biomechanical responses detected using corvis st in primary open angle glaucoma and normal tension glaucoma
| Autor: | Younhea Jung, Chan Kee Park, Sieun Oh, Hae-Young Lopilly Park |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Intraocular pressure medicine.medical_specialty primary open-angle glaucoma genetic structures Open angle glaucoma Scheimpflug principle Observational Study Glaucoma Spherical equivalent law.invention Cornea Tonometry Ocular 03 medical and health sciences 0302 clinical medicine law Normal tension glaucoma Ophthalmology medicine Humans Low Tension Glaucoma 030212 general & internal medicine Intraocular Pressure Aged Retrospective Studies Keratometer business.industry normal-tension glaucoma General Medicine Middle Aged medicine.disease eye diseases Normal group Case-Control Studies 030220 oncology & carcinogenesis Female sense organs corneal biomechanics business Glaucoma Open-Angle Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Structural differences have been reported between primary open angle glaucoma (POAG) and normal tension glaucoma (NTG), and biomechanical differences between POAG and NTG may account for why NTG patients are more vulnerable to lower intraocular pressure (IOP). This study compared the biomechanical properties of POAG and NTG patients using the Corvis scheimpflug technology (ST) non-contact Scheimpflug-based tonometer, and determined the factors associated with these properties. In this retrospective cross-sectional study, 46 eyes with POAG, 54 eyes with NTG, and 61 control eyes were included. A non-contact Scheimpflug-based tonometer was used to examine and compare the corneal biomechanical responses in the POAG, NTG, and normal groups. We used univariate and multivariate regression analyses to determine the factors associated with the deformation amplitude in each group. Baseline characteristics, including age, IOP, spherical equivalent, keratometry, axial length, and central corneal thickness, were similar among the 3 groups. Severity of glaucoma, as measured by mean deviation, was similar between POAG and NTG groups. Applanation 1 velocity and deformation amplitude were significantly smaller in POAG (0.13 ± 0.02 and 1.06 ± 0.14, respectively) than NTG (0.14 ± 0.01 and 1.13 ± 0.11, respectively) and normal groups (0.14 ± 0.02 and 1.13 ± 0.10, respectively). Radius of curvature was significantly larger in the POAG group compared to the normal group. In normal controls, IOP and keratometry were significant factors related to deformation amplitude. In POAG eyes, IOP was a statistically significant predictor of deformation amplitude. In NTG eyes, however, IOP , keratometry, and axial length were statistically significant predictors of deformation amplitude. POAG eyes showed less deformable corneas compared to NTG and normal controls. IOP was significantly correlated with deformation amplitude in all groups. However, axial length was positively correlated with deformation amplitude only in NTG eyes. Characterization of the differences in biomechanical properties between POAG and NTG may contribute to a better understanding of the underlying pathophysiologies associated with these diseases. |
| Databáze: | OpenAIRE |
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