Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data
| Autor: | Daryl T. Baldwin, P M Williams, Wenjun Ouyang, Paulj. Godowski, Flavius Martin, M. van Lookeren Campagne, Alexander R. Abbas, Andrew C. Chan, A. Gurney, Hilary Clark, Sherman Fong, Y Ma |
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| Rok vydání: | 2005 |
| Předmět: |
Genetics
Gene Expression Profiling animal diseases In silico Immunology Immunity chemical and pharmacologic phenomena Computational biology Immunogenetics biochemical phenomena metabolism and nutrition Biology Acquired immune system Immune system Gene Expression Regulation Humans bacteria Gene family Signal transduction Gene Genetics (clinical) Cellular localization Oligonucleotide Array Sequence Analysis Signal Transduction |
| Zdroj: | Genes & Immunity. 6:319-331 |
| ISSN: | 1476-5470 1466-4879 |
| DOI: | 10.1038/sj.gene.6364173 |
| Popis: | Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. We have compiled a compendium of microarray expression data for virtually all human genes from six key immune cell types and their activated and differentiated states. Immune Response In Silico (IRIS) is a collection of genes that have been selected for specific expression in immune cells. The expression pattern of IRIS genes recapitulates the phylogeny of immune cells in terms of the lineages of their differentiation. Gene Ontology assignments for IRIS genes reveal significant involvement in inflammation and immunity. Genes encoding CD antigens, cytokines, integrins and many other gene families playing key roles in the immune response are highly represented. IRIS also includes proteins of unknown function and expressed sequence tags that may not represent genes. The predicted cellular localization of IRIS proteins is evenly distributed between cell surface and intracellular compartments, indicating that immune specificity is important at many points in the signaling pathways of the immune response. IRIS provides a resource for further investigation into the function of the immune system and immune diseases. |
| Databáze: | OpenAIRE |
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