In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products
| Autor: | Bent H. Hellum, Ole Kristian Forstrønen Thu, Odd G. Nilsen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pharmaceutical Science
Pharmacology digestive system 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cytochrome P-450 Enzyme System Drug Discovery medicine Humans Enzyme Inhibitors biology Dose-Response Relationship Drug Plant Extracts Salidroside CYP1A2 Commerce Rosavin General Medicine biology.organism_classification Rosarin Crassulaceae Tyrosol Enzyme Activation Rhodiola rosea Complementary and alternative medicine chemistry Phenacetin 030220 oncology & carcinogenesis Molecular Medicine Rhodiola medicine.drug |
| Zdroj: | Pharmaceutical biology. 54(12) |
| ISSN: | 1744-5116 |
| Popis: | Rhodiola rosea L. (Crassulaceae) products are popular natural remedies with a worldwide distribution. Recent studies have revealed potent CYP inhibition by R. rosea extracts both in vitro and in vivo, but information on in vitro CYP inhibition by commercial products are lacking. Variations in commercial R. rosea product quality have also been published.This study evaluates the variation of in vitro CYP inhibition potential and product quality of six commercially available R. rosea products.Human CYPs isolated from baculovirus-infected cell system were incubated with testosterone (CYP3A4), dextromethorphan (CYP2D6) or phenacetin (CYP1A2). Positive CYP inhibitors ketoconazole (CYP3A4), quinidine (CYP2D6) and β-naphtoflavone (CYP1A2) were used as controls. Quantification of rosavin, rosarin, rosin, tyrosol and salidroside were used to evaluate R. rosea content.ICThe present results show a large variation in inhibitory potential between the products. Several of the products demonstrate similar inhibition levels as the product Arctic Root already proven to inhibit CYP enzyme activity in man. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |