Secretory antibodies to citrullinated peptides in plasma and saliva from rheumatoid arthritis patients and their unaffected first-degree relatives

Autor: K Roos Ljungberg, Christopher Sjöwall, Alf Kastbom, Klara Martinsson, Mikael Brink, Anna Svärd, S. Rantapää Dahlqvist
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
relatives
rheumatoid arthritis
Saliva
Arthritis
Rheumatoid
0302 clinical medicine
immune system diseases
Immunology and Allergy
Longitudinal Studies
skin and connective tissue diseases
mucosa
Aged
80 and over
biology
Smoking
Middle Aged
Rheumatoid arthritis
Autoimmunity/Autoimmune disease
Original Article
Female
Antibody
Adult
musculoskeletal diseases
Secretory antibody
Immunology
Gastroenterology and Hepatology
Peptides
Cyclic
03 medical and health sciences
ACPA
secretory immunoglobulin
medicine
Gastroenterologi
Humans
Family
First-degree relatives
Salivary Proteins and Peptides
Aged
Autoantibodies
Rheumatology and Autoimmunity
Reumatologi och inflammation
business.industry
Original Articles
medicine.disease
Immunoglobulin A
030104 developmental biology
biology.protein
business
030215 immunology
Zdroj: Clinical and Experimental Immunology
Popis: Summary The aim of this study was to evaluate secretory antibodies to citrullinated proteins (ACPA) in plasma and immunoglobulin (Ig)A ACPA in saliva from patients with rheumatoid arthritis (RA) and their unaffected first‐degree relatives (FDRs). Patients with RA (n = 194) and first‐degree relatives unaffected by RA (n = 191) were recruited for analysis of secretory antibodies to second‐generation cyclic citrullinated peptides (anti‐CCP) in plasma. From a subpopulation (25 RA patients, 21 first‐degree relatives and 11 controls), saliva samples were obtained for IgA anti‐CCP analysis. The presence of secretory ACPA was compared between subject categories, and related to genetic and environmental risk factors. Secretory ACPA occurred in 37 (19%) plasma samples from patients with RA, but only in two (1%) of FDRs. IgA ACPA in saliva was found in three of 25 (12%) patients with RA, but not in any of the 21 FDRs (
We hypothesized that mucosa‐associated anti‐citrullinated protein antibodies (ACPA) would be increased in first‐degree relatives to rheumatoid arthritis (RA) patients, as mucosal involvement has been suggested in early steps of RA pathogenesis and FDRs are at increased risk of developing the disease. However, circulating secretory ACPA and salivary IgA ACPA were rare in FDRs despite substantial occurrence in RA patients. These results do not support mucosal ACPA production as early steps of RA development but highlight the need for longitudinal studies of at‐risk populations.
Databáze: OpenAIRE
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