Secretory antibodies to citrullinated peptides in plasma and saliva from rheumatoid arthritis patients and their unaffected first-degree relatives
Autor: | K Roos Ljungberg, Christopher Sjöwall, Alf Kastbom, Klara Martinsson, Mikael Brink, Anna Svärd, S. Rantapää Dahlqvist |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Male relatives rheumatoid arthritis Saliva Arthritis Rheumatoid 0302 clinical medicine immune system diseases Immunology and Allergy Longitudinal Studies skin and connective tissue diseases mucosa Aged 80 and over biology Smoking Middle Aged Rheumatoid arthritis Autoimmunity/Autoimmune disease Original Article Female Antibody Adult musculoskeletal diseases Secretory antibody Immunology Gastroenterology and Hepatology Peptides Cyclic 03 medical and health sciences ACPA secretory immunoglobulin medicine Gastroenterologi Humans Family First-degree relatives Salivary Proteins and Peptides Aged Autoantibodies Rheumatology and Autoimmunity Reumatologi och inflammation business.industry Original Articles medicine.disease Immunoglobulin A 030104 developmental biology biology.protein business 030215 immunology |
Zdroj: | Clinical and Experimental Immunology |
Popis: | Summary The aim of this study was to evaluate secretory antibodies to citrullinated proteins (ACPA) in plasma and immunoglobulin (Ig)A ACPA in saliva from patients with rheumatoid arthritis (RA) and their unaffected first‐degree relatives (FDRs). Patients with RA (n = 194) and first‐degree relatives unaffected by RA (n = 191) were recruited for analysis of secretory antibodies to second‐generation cyclic citrullinated peptides (anti‐CCP) in plasma. From a subpopulation (25 RA patients, 21 first‐degree relatives and 11 controls), saliva samples were obtained for IgA anti‐CCP analysis. The presence of secretory ACPA was compared between subject categories, and related to genetic and environmental risk factors. Secretory ACPA occurred in 37 (19%) plasma samples from patients with RA, but only in two (1%) of FDRs. IgA ACPA in saliva was found in three of 25 (12%) patients with RA, but not in any of the 21 FDRs ( We hypothesized that mucosa‐associated anti‐citrullinated protein antibodies (ACPA) would be increased in first‐degree relatives to rheumatoid arthritis (RA) patients, as mucosal involvement has been suggested in early steps of RA pathogenesis and FDRs are at increased risk of developing the disease. However, circulating secretory ACPA and salivary IgA ACPA were rare in FDRs despite substantial occurrence in RA patients. These results do not support mucosal ACPA production as early steps of RA development but highlight the need for longitudinal studies of at‐risk populations. |
Databáze: | OpenAIRE |
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