Effects of SC-52458, a new nonpeptide angiotensin II receptor antagonist, on increase in cytoplasmic Ca2+ concentrations and contraction induced by angiotensin II and K+-depolarization in guinea-pig taenia coli
| Autor: | Sadaharu Usune, Tatsuo Furukawa |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Atropine
Male Cytoplasm medicine.medical_specialty Contraction (grammar) Colon Pyridines medicine.drug_class Guinea Pigs Tetrazoles Angiotensin-Converting Enzyme Inhibitors Angiotensin II receptor antagonist Tetrodotoxin In Vitro Techniques Biology 1-Sarcosine-8-Isoleucine Angiotensin II Angiotensin Receptor Antagonists Internal medicine medicine Animals Receptor Antihypertensive Agents Pharmacology Angiotensin II receptor type 1 Angiotensin II Parasympatholytics Muscle Smooth Receptor antagonist Taenia coli Endocrinology medicine.anatomical_structure Neuromuscular Depolarizing Agents Potassium Calcium medicine.symptom Muscle Contraction Muscle contraction |
| Zdroj: | General Pharmacology: The Vascular System. 27:1179-1185 |
| ISSN: | 0306-3623 |
| DOI: | 10.1016/s0306-3623(96)00058-4 |
| Popis: | 1. 1. The effects of angiotensin (Ang) II receptor antagonist, SC-52458, on peak and plateau components of Ang II-induced contraction were evaluated in the guinea-pig taenia coli. 2. 2. SC-52458 suppressed both the components of and increases in cytoplasmic Ca2+ concentrations, [Ca2+]i, coupled with the contraction by Ang II; tetrodotoxin and atropine did not affect the contractions. 3. 3. SC-52458 inhibited a plateau component of the contraction induced by K+-depolarization to some extent, without affecting a peak component. 4. 4. SC-52458 suppressed both the contraction and increase of [Ca2+]i by antagonizing AT1 receptors in the smooth muscle. |
| Databáze: | OpenAIRE |
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