Nanomedicinal strategies as efficient therapeutic interventions for delivery of cancer vaccines
Autor: | Sunil K. Panda, Mohammed Tarique, Mahfoozur Rahman, Sarah Afaq, Kainat Alam, S.M. Kawish, Sarwar Beg, Arshi Malik, Jawed Iqbal, Awad S. Alsamghan |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Genetic enhancement Antineoplastic Agents Cancer Vaccines 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Pharmacotherapy Neoplasms medicine Animals Humans Intensive care medicine business.industry Vaccination Cancer medicine.disease Review article Nanomedicine 030104 developmental biology Biopharmaceutical Targeted drug delivery 030220 oncology & carcinogenesis Cancer vaccine Nanocarriers business |
Zdroj: | Seminars in Cancer Biology. 69:43-51 |
ISSN: | 1044-579X |
Popis: | The applications of gene therapy-based treatment of cancers were started almost two decades back as a boon over the chemotherapeutic treatment strategies. Gene therapy helps in correcting the genetic sequences for treatment of cancers, thus also acts like a vaccine to induce the cellular and humoral immunity. However, the cancer vaccines typically suffer from a series of biopharmaceutical challenges due to poor solubility, low systemic availability and lack of targeting ability. Owing to these challenges, the physicians and pharmaceutical scientists have explored the applications of nanocarriers as quite promising systems for effective treatment against the tumors. A series of nanotherapeutic systems are available to date for diverse drug therapy applications. Systematic understanding on the preparation, evaluation and application of nanomedicines as a carrier system for delivering the cancer vaccines is highly important. The present review article provides an in-depth understanding on the challenges associated with cancer vaccine delivery and current opportunities with diverse nanomedicinal carriers being available for treatment of cancers. |
Databáze: | OpenAIRE |
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