Testicular Adrenal Rest Tumors and Leydig and Sertoli Cell Function in Boys with Classical Congenital Adrenal Hyperplasia
| Autor: | Ana Rocha, N. Rojas, Marcela Lagos, Helena Poggi, C. García, L. Valdivia, R. Parra, Andreina Cattani, Alejandro Martinez-Aguayo |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Anti-Mullerian Hormone
Male medicine.medical_specialty Adrenal Rest Tumor medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Context (language use) Biochemistry Endocrinology Testicular Neoplasms Internal medicine medicine Humans Inhibins Congenital adrenal hyperplasia Child Testosterone Sertoli Cells Adrenal Hyperplasia Congenital Anthropometry Leydig cell biology Biochemistry (medical) Leydig Cells Anti-Müllerian hormone DNA medicine.disease Sertoli cell Hormones medicine.anatomical_structure Child Preschool biology.protein Gonadotropin |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 92:4583-4589 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Context: Infertility observed in adult males with congenital adrenal hyperplasia (CAH) has been associated with testicular adrenal rest tumors (TART) that may originate during childhood. Objective: Our objective was to describe the prevalence of TART and Sertoli and Leydig cell function in a group of boys aged 2–10 yr with CAH and to compare prevalence with that of a control group. Design: From August 2005 to January 2007, 19 patients with classical CAH (CAH group) were referred from seven endocrinology centers. Methods: We studied 19 subjects in the CAH group and, as a control group, 13 boys from the community that did not have testicular diseases. A complete physical exam was performed. High-resolution ultrasound was used to determine TART prevalence. Inhibin B and anti-Müllerian hormone were used as Sertoli cell markers. The ratio between basal testosterone levels and testosterone levels 72 h after β-human chorionic gonadotropin (5000 U/m2) treatment [(T72− T0)/T0] was used to evaluate Leydig cell response. Results: CAH and control groups were comparable in chronological age (5.9 vs. 5.6 yr; P = 0.67) and bone age/chronological age ratio (1.09 vs. 1.03; P = 0.09). TART prevalence was four of 19 (21%) in the CAH group. Lower values for inhibin B (49.2. vs. 65.2 pg/ml; P = 0.018), anti-Müllerian hormone (70.1 vs. 94.2 ng/ml; P = 0.002), and (T72− T0)/T0 (5.6 vs. 13.6; P < 0.01) were observed in the CAH group. Conclusion: TART in prepubertal males with classic CAH could be found during childhood. We also report differences in markers of gonadal function in a subgroup of patients, especially in those with inadequate control. |
| Databáze: | OpenAIRE |
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