Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging

Autor: Ann E. Elsner, Yoshiaki Yasuno, Masahiro Miura, Hiroshi Goto, Shuichi Makita, Takuya Iwasaki, Young-Joo Hong, Rintaro Tsukahara, Shigeo Tamiya, Satoshi Sugiyama
Rok vydání: 2017
Předmět:
Male
genetic structures
Retinal Pigment Epithelium
01 natural sciences
Macular Degeneration
chemistry.chemical_compound
0302 clinical medicine
Cell Movement
Prospective Studies
Aged
80 and over
Multidisciplinary
medicine.diagnostic_test
Optical Imaging
Middle Aged
Serous fluid
medicine.anatomical_structure
Scanning Laser Polarimetry
visual_art
Disease Progression
visual_art.visual_art_medium
Medicine
Female
Tomography
Optical Coherence
medicine.medical_specialty
Science
Retinal Drusen
Article
010309 optics
03 medical and health sciences
Pigment
Optical coherence tomography
Age related
Ophthalmology
0103 physical sciences
medicine
Humans
Aged
Retinal pigment epithelium
Retinal Detachment
Epithelial Cells
Retinal
Macular degeneration
medicine.disease
eye diseases
Ophthalmoscopy
Autofluorescence
chemistry
030221 ophthalmology & optometry
Optometry
sense organs
Zdroj: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-017-03529-8
Popis: The purpose of the present study was to evaluate the intraretinal migration of the retinal pigment epithelium (RPE) cells in age-related macular degeneration (AMD) using polarimetry. We evaluated 155 eyes at various AMD stages. Depolarized light images were computed using a polarization-sensitive scanning laser ophthalmoscope (PS-SLO), and the degree of polarization uniformity was calculated using polarization-sensitive optical coherence tomography (OCT). Each polarimetry image was compared with the corresponding autofluorescence (AF) images at 488 nm (SW-AF) and at 787 nm (NIR-AF). Intraretinal RPE migration was defined by the presence of depolarization at intraretinal hyperreflective foci on PS-SLO and PS-OCT images, and by the presence of hyper-AF on both NIR-AF and SW-AF images. RPE migration was detected in 52 of 155 eyes (33.5%) and was observed in drusenoid pigment epithelial detachment (PED) and serous PED with significantly higher frequencies than in other groups (P = 0.015). The volume of the migrated RPE cluster in serous PED was significantly correlated with the volume of the PED (R2 = 0.26; P = 0.011). Overall, our results showed that intraretinal RPE migrations occurred in various AMD stages, and that they occurred more commonly in eyes with serous and drusenoid PED.
Databáze: OpenAIRE
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