Polyoxygenated cyclohexene derivatives and flavonoids from the leaves of Uvaria pandensis
| Autor: | Maeda, Gasper, Gilissen, Pieter J., Bourgard, Catarina, van der Wal, Jelle, Munissi, Joan J.E., Nyandoro, Stephen S., Erdelyi, Mate |
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| Rok vydání: | 2022 |
| Předmět: |
Flavonoids
Pharmacology History Polymers and Plastics Molecular Structure General Medicine Industrial and Manufacturing Engineering Anti-Bacterial Agents Plant Leaves Cyclohexenes Drug Discovery NMR natural product pandensenol flavanoid pandensone Humans Business and International Management Uvaria Physical Organic Chemistry Bacillus subtilis |
| Zdroj: | Fitoterapia, 158, pp. 1-7 Fitoterapia, 158, 1-7 |
| ISSN: | 0367-326X |
| Popis: | Three new oxygenated cyclohexene derivatives, pandensenol D - F (1-3), two new flavanoids, pandensone A and B (4-5), and seven known compounds (6-12) were isolated from the methanol extract of the leaves of Uvaria pandensis Verdc. (Annonaceae). The structures were characterized by NMR spectroscopic and mass spectrometric analyses. The isolated metabolites were evaluated for their antibacterial activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus epidermidis, the Gram-negative bacteria Enterococcus raffinosus, Escherichia coli, Paraburkholderia caledonica, Pectobacterium carotovorum and Pseudomonas putida, and for cytotoxicity against the MCF-7 human breast cancer cell line. Out of the tested compounds, pandensenol D (1) and (6',7'-dihydro-8'α,9'β-dihydroxy)-3-farnesylindole (12) showed weak activity, whereas (8'α,9'β-dihydroxy)-3-farnesylindole (11) strong activity against B. subtilis. Four of the isolated compounds (1, 4, 11 and 12) showed moderate cytotoxicity against MCF-7 breast cancer cells (EC |
| Databáze: | OpenAIRE |
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