Molecular epidemiology of rotavirus gastroenteritis in Japan during 2014-2015: Characterization of re-emerging G2P[4] after rotavirus vaccine introduction
| Autor: | Nusrat Khandoker, Hiroshi Ushijima, Satoshi Hayakawa, Masaaki Kobayashi, Aksara Thongprachum, Masashi Mizuguchi, Shoko Okitsu, Sayaka Takanashi, Tsuneyoshi Baba, Atsuko Yamamoto, Kumiko Sugita, Hideaki Kikuta, Shuichi Nishimura |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Rotavirus 0301 basic medicine Genotype Sequence Homology Biology medicine.disease_cause Communicable Diseases Emerging Group A Rotavirus Infections Epitope Epitopes Feces 03 medical and health sciences Japan Virology medicine Cluster Analysis Humans Child Antigens Viral Molecular Epidemiology Molecular epidemiology Rotavirus Vaccines Infant Sequence Analysis DNA Rotavirus vaccine Gastroenteritis Vaccination 030104 developmental biology Infectious Diseases Amino Acid Substitution Child Preschool Capsid Proteins Female Follow-Up Studies |
| Zdroj: | Journal of Medical Virology. 90:1040-1046 |
| ISSN: | 0146-6615 |
| Popis: | Rotavirus vaccines have been available in Japan since 2011. This study conducted to monitor the trend of group A rotavirus (RVA) genotypes 3 years after vaccine introduction. A total of, 539 fecal samples were collected from children with acute gastroenteritis in six regions during July 2014-June 2015. Among them, 178 samples (33.0%) were positive for RVA. The most predominant genotype was G1P[8] (35.9%) followed by G2P[4] (26.4%), G9P[8] (21.3%), G3P[8] (4.5%), and G3P[9] (4.5%). The detection rate of G2P[4] was increased soon after vaccine introduction. Sequence analyses of VP7 and VP4 genes of the representative G2P[4] strains were found to be clustered in sub-lineage IVa of lineage IV. It is noteworthy that one amino acid substitution in the antigenic epitope (Q114P) of VP4 gene was found in representative G2P[4] strains of the current study. However, it is unclear whether the change in antigenic epitope is due to the effect of vaccination or due to natural variation, warranting further continuous monitoring of rotavirus evolution after vaccine introduction. |
| Databáze: | OpenAIRE |
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