Autoimmune lymphoproliferative disorder in an adult patient
| Autor: | A R Pazare, S Bajpai, N K Desai, S Morkhandikar |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_specialty Tuberculosis Fever lcsh:Medicine Acquired immunodeficiency syndrome (AIDS) lymphadenopathy Biopsy medicine Humans Lymph node Castleman′s disease medicine.diagnostic_test business.industry lcsh:R Autoimmune Lymphoproliferative Syndrome General Medicine Hyperplasia Middle Aged medicine.disease Dermatology Autoimmune lymphoproliferation double negative lymphocytes medicine.anatomical_structure Epistaxis Immunohistochemistry Sarcoidosis Lymph Nodes business CD8 |
| Zdroj: | Journal of Postgraduate Medicine, Vol 57, Iss 2, Pp 131-133 (2011) |
| ISSN: | 0972-2823 |
| Popis: | A 50-year-old male patient presented with fever, epistaxis and multiple lymphadenopathy since 15 days. In the light of the above presentation a complete workup was initiated to exclude common conditions like tuberculosis, acquired immunodeficiency syndrome, lymphoid malignancy and sarcoidosis. After excluding common conditions a biopsy of cervical lymph node demonstrated reactive lymphadenitis with paracortical hyperplasia. Immunohistochemistry demonstrated double negative lymphocytes (CD4-, CD8-). A diagnosis of autoimmune lymphoproliferative disorder syndrome (ALPS) (probable) was made and patient was started on 1 mg/kg of steroids. Patient showed a dramatic improvement with respect to general wellbeing, fever and regression of lymphadenopathy. This entity of ALPS has been recently identified and classified; most of the reports are from the pediatric population. To the best of our knowledge ours is one of the few cases of this entity being reported in an adult patient from India. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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