Associations of sex-hormone-binding globulin (SHBG) with non-SHBG-bound levels of testosterone and estradiol in independently living men
| Autor: | Majon Muller, Yvonne T. van der Schouw, Frank H. de Jong, Louis Gooren, Willem de Ronde, Diederick E. Grobbee, Huibert A. P. Pols |
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| Přispěvatelé: | Internal Medicine, Internal medicine, ACS - Atherosclerosis & ischemic syndromes, University of Groningen |
| Rok vydání: | 2005 |
| Předmět: |
HYPERTHYROIDISM
Adult Male medicine.medical_specialty medicine.drug_class PROTEINS Endocrinology Diabetes and Metabolism Clinical Biochemistry Biochemistry Endocrinology Sex hormone-binding globulin Internal medicine Sex Hormone-Binding Globulin 80 and over medicine polycyclic compounds Journal Article Humans Testosterone Beta (finance) HUMAN-PLASMA reproductive and urinary physiology Aged Aged 80 and over biology Estradiol STEROIDS Biochemistry (medical) PITUITARY-TESTICULAR AXIS SITE Liter Luteinizing Hormone Middle Aged Androgen ANDROGEN Cross-Sectional Studies METABOLIC-CLEARANCE Estrogen MALES SERUM LEVELS biology.protein Luteinizing hormone hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 90(1), 157-162. Endocrine Society Journal of Clinical Endocrinology and Metabolism, 90(1), 157-162. The Endocrine Society Journal of Clinical Endocrinology and Metabolism, 90(1), 157-162. ENDOCRINE SOC De Ronde, W, Van Der Schouw, Y T, Muller, M, Grobbee, D E, Gooren, L J G, Pols, H A P & De Jong, F H 2005, ' Associations of Sex-Hormone-Binding Globulin (SHBG) with Non-SHBG-Bound levels of testosterone and estradiol in independently living men ', Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 1, pp. 157-162 . https://doi.org/10.1210/jc.2004-0422 Journal of Clinical Endocrinology and Metabolism, 90(1), 157. The Endocrine Society |
| ISSN: | 0021-972X |
| Popis: | Results of in vitro experiments indicate that with increasing concentrations of SHBG, testosterone ( T) is preferentially bound to SHBG in comparison with estradiol (E2). In these studies, the ratio of non-SHBG-bound E2 (non-SHBG-E2) to non-SHBG-T increased with increasing levels of SHBG. SHBG has consequently been regarded as an estrogen amplifier. In this cross-sectional study in 399 men aged between 40 and 80 yr we tested whether higher levels of SHBG are associated with a higher estrogen/androgen ratio in vivo. The mean T level of these men was in the eugonadal range [536 +/- 152 ng/dl (18.6 +/- 5.26 nmol/liter), mean +/- SD]. With increasing SHBG levels the non-SHBG-bound fraction of T decreased from 80 to 36% and that of E2 from 89 to 53%. Higher levels of SHBG were associated with higher levels of both total T [ regression coefficient (beta) after adjustment for age and body mass index, 286 +/- 15.8; P |
| Databáze: | OpenAIRE |
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