Scintigraphic assessment of salivary function after intensity-modulated radiotherapy for head and neck cancer: correlations with parotid dose and quality of life
| Autor: | Tsair-Fwu Lee, Chao-Hsiung Hung, Chia-Hsuan Lai, Fu-Ming Fang, Wen-Hung Wang, Hungcheng Chen, Wen-Cheng Chen, Miao-Fen Chen, Ming-Fong Tsai, Kuo-Chi Liu |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty medicine.medical_treatment Submandibular Gland Scintigraphy Xerostomia Salivary function Quality of life Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Parotid Gland Longitudinal Studies Prospective Studies Radionuclide Imaging Saliva Aged medicine.diagnostic_test business.industry Head and neck cancer Dose-Response Relationship Radiation Radiotherapy Dosage Recovery of Function Middle Aged medicine.disease Neoadjuvant Therapy Radiotherapy Computer-Assisted Radiation therapy stomatognathic diseases Chemotherapy Adjuvant Head and Neck Neoplasms Quality of Life Female Radiology Intensity modulated radiotherapy Radiotherapy Intensity-Modulated Oral Surgery business Follow-Up Studies |
| Zdroj: | Oral oncology. 49(1) |
| ISSN: | 1879-0593 |
| Popis: | We investigated salivary function using quantitative scintigraphy and sought to identify functional correlations between parotid dose and quality of life (QoL) for head and neck cancer (HNC) patients receiving intensity-modulated radiotherapy (IMRT).Between August, 2007 and June, 2008, 31 patients treated IMRT for HNC were enrolled in this prospective study. Salivary excretion function (SEF) was previously measured by salivary scintigraphy at annual intervals for 2 years after IMRT. A dose-volume histogram of each parotid gland was calculated, and the normal tissue complication probability (NTCP) was used to determine the tolerance dose. QoL was longitudinally assessed by the EORTC QLQ-C30 and HN35 questionnaires prior to RT, and at one, three, 12 and 24 months after RT.A significant correlation was found between the reduction of SEF and the mean parotid dose measured at 1 year (correlation coefficient, R(2)=0.651) and 2 years (R(2)=0.310) after IMRT (p0.001). The TD(50) of the parotid gland at 1 year after IMRT is 43.6 Gy, comparable to results from western countries. We further found that contralateral parotid and submandibular gland function preservation was correlated with reduced sticky saliva and a better QoL compared to the functional preservation of both parotid glands, as determined by the EORTC QLQ-HN35 questionnaire.A significant correlation was found between the reduction of SEF and the mean parotid dose. Preservation of contralateral parotid and submandibular gland function predicts a better QoL compared to preservation of the function of both parotid glands. |
| Databáze: | OpenAIRE |
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