Pulmonary vagal innervation is required to establish adequate alveolar ventilation in the newborn lamb
| Autor: | Baikhunth Bharadwaj, Samuel Schürch, Kevin Wong, Shabih U. Hasan, Anita Rigaux, Bing Wang, John E. Remmers, Ather Bano, Francis H. Y. Green |
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| Rok vydání: | 1998 |
| Předmět: |
Pulmonary Circulation
Respiratory rate Physiology Diaphragmatic breathing Atelectasis Vagotomy Body Temperature Hypoxemia Pregnancy Physiology (medical) medicine Animals Lung Sheep business.industry Hemodynamics Vagus Nerve Organ Size medicine.disease Pulmonary Alveoli Respiratory acidosis medicine.anatomical_structure Animals Newborn Respiratory failure Anesthesia Respiratory Physiological Phenomena Breathing Female Blood Gas Analysis medicine.symptom Respiratory Insufficiency business |
| Zdroj: | Journal of Applied Physiology. 85:849-859 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1998.85.3.849 |
| Popis: | To investigate the effects of bilateral intrathoracic vagotomy on the establishment of continuous breathing and effective gas exchange at birth, we studied 8 chronically instrumented, unanesthetized, sham-operated and 14 vagotomized newborn lambs after a spontaneous, unassisted vaginal delivery. Fetal lambs were instrumented in utero to record sleep states, diaphragmatic electromyogram, blood pressure, arterial pH, and blood-gas tensions. Six of eight sham-operated lambs established effective gas exchange within 10 min of birth, whereas 12 of 14 vagotomized animals developed respiratory acidosis and hypoxemia ( P= 0.008). Breathing frequency in vagotomized newborns was significantly lower during the entire postnatal period compared with sham-operated newborns. Vagotomized subjects also remained hypothermic during the entire postnatal period ( P < 0.05). Bronchoalveolar lavage indicated an increased minimum surface tension, whereas lung histology showed perivascular edema and partial atelectasis in the vagotomized group. We conclude that stimulation of breathing and effective gas exchange are critically dependent on intact vagal nerves during the transition from fetal to neonatal life. |
| Databáze: | OpenAIRE |
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