A novel prognostic biomarker for recurrent aphthous stomatitis: calprotectin
| Autor: | Ihsan Kuzucu, Serkan Kayabasi |
|---|---|
| Přispěvatelé: | Tıp Fakültesi |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Inflammation Recurrent aphthous stomatitis Gastroenterology 03 medical and health sciences fluids and secretions 0302 clinical medicine Recurrence Internal medicine Healthy volunteers medicine Humans Lesion group In patient Prognostic biomarker Prospective Studies 030223 otorhinolaryngology Stomatitis business.industry Aphthous 030206 dentistry General Medicine Middle Aged Prognosis medicine.disease Cross-Sectional Studies Otorhinolaryngology Case-Control Studies Female Stomatitis Aphthous medicine.symptom Calprotectin business Leukocyte L1 Antigen Complex Biomarkers |
| Zdroj: | The Journal of Laryngology & Otology. 133:691-695 |
| ISSN: | 1748-5460 0022-2151 |
| DOI: | 10.1017/s0022215119001440 |
| Popis: | Objective. This study aims to investigate whether there is a correlation between serum calprotectin concentration and oral ulcer activity in patients with active recurrent aphthous stomatitis. Method. This prospective, cross-sectional, historical cohort study included 52 patients (26 with active lesions and 26 with inactive lesions) with recurrent aphthous stomatitis and 27 healthy volunteers. The relationship between the groups was statistically evaluated in terms of serum calprotectin level and other inflammatory parameters. Results. The median calprotectin value of the active lesion group (803 ng/ml) was significantly higher than that of the control group (55.4 ng/ml, p = 0.002). Furthermore, the median calprotectin value of the active lesion group was significantly higher than that of the inactive lesion group (72.5 ng/ml, p = 0.017). Conclusion. In patients with recurrent aphthous stomatitis and active ulcer lesions, the serum calprotectin value can be used as a reliable and robust prognostic marker for inflammation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|