Noninvasive detection of Helicobacter pylori colonization in stomach using [11C]urea
| Autor: | Nicholas Nickl, Ryo Uy, Michael Jay, Ranajit K. Bera, Hill Db, Neil G. Hartman |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Chest Pain Urease Physiology Gastroenterology chemistry.chemical_compound Internal medicine Biopsy medicine Humans Carbon Radioisotopes Endoscopy Digestive System Breath test Gastric emptying medicine.diagnostic_test biology Helicobacter pylori Stomach digestive oral and skin physiology Middle Aged biology.organism_classification medicine.anatomical_structure chemistry Breath Tests Gastritis Urea biology.protein medicine.symptom |
| Zdroj: | Digestive diseases and sciences. 37(4) |
| ISSN: | 0163-2116 |
| Popis: | Helicobacter pylori is associated with chronic type B gastritis. Diagnosis can be made on gastric biopsy specimens and noninvasively using [13C]- or [14C]urea breath tests. Both breath tests require meticulous breath collection, and false positive results are possible from urease producing oral-pharyngeal flora. We used [11C]urea, a positron-emitting radionuclide allowing dynamic imaging, to measure metabolism of urea in the stomach of biopsy documented H. pylori-positive patients. [11C]urea was synthesized from 11CO2 produced using a Van de Graaff accelerator and administered with [99mTc]DTPA to control for loss of radioactivity via gastric emptying. Images were obtained externally by gamma camera every minute and 11CO2 was monitored in the breath continuously for 30 min. An H. pylori-positive patient exhibited a 99mTc/11C activity ratio of 2:1 in the stomach 10-20 min following administration, compared to a 1:1 ratio in a negative control, indicating metabolism of urea to 11CO2 with subsequent diffusion of 11C activity out of the stomach. The 11C activity in the breath peaked at 10-20 min in the H. pylori-positive patients. The short half-life of carbon-11 (20.4 min) alleviates radiation safety concerns and results in low absorbed radiation doses to patients. |
| Databáze: | OpenAIRE |
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