Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study
| Autor: | Geeta A. Thakur, Vivian Akerib, Jorge L. Armony, Annie-Claude David, Isabelle Rouleau, Alain Brunet |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Persistence (psychology)
Memory Dysfunction lcsh:BF1-990 Single-nucleotide polymorphism Development Article 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Glucocorticoid receptor remission Canadians mental disorders Genetics glucocorticoid receptor Gene General Psychology Ecology Evolution Behavior and Systematics FKBP5 Gene 030227 psychiatry Posttraumatic stress FKBP5 lcsh:Psychology HPA-axis Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Behavioral Sciences, Vol 2, Iss 2, Pp 103-114 (2012) Behavioral Sciences Volume 2 Issue 2 Pages 103-114 |
| Popis: | The FKBP5 gene, a glucocorticoid receptor (GR)-regulating co-chaperone of stress proteins, is of special interest because of its role in hypothalamic-pituitary-adrenal (HPA)-axis regulation. However, studies finding a genetic relationship between posttraumatic stress disorder (PTSD) and the FKBP5 gene have failed to distinguish between the development and persistence of PTSD, thereby limiting the prognostic usefulness of such a finding. The present study sought to longitudinally explore this question by examining the association between four single-nucleotide polymorphisms (SNPs) in the FKBP5 gene (rs3800373, rs9470080, rs1360780, and rs9296158), the persistence of PTSD (severity and diagnostic status), and memory performance among twenty-two treatment-seekers diagnosed with acute PTSD. Results showed that the four SNPs significantly interacted with improvement in PTSD symptoms as well as PTSD diagnostic status. Individuals homozygous for the dominant allele and having experienced higher levels of peritraumatic responses subsequently showed more memory dysfunction. The results of this study suggest that SNPs in the FKBP5 gene are associated with symptom persistence and memory dysfunction in acute PTSD. |
| Databáze: | OpenAIRE |
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