Surveillance of transcriptomes in basic military trainees with normal, febrile respiratory illness, and convalescent phenotypes

Autor:	J. Diao, Elizabeth A. Walter, H. Melgarejo, B. Johnson, Dzung Thach, D. Watson, Eric H. Hanson, J. Fuller, Gary Vora, M. Jesse, Zheng Wang, K. Russell, N. Freed, Jose Santiago, J. Gomez, P. Demitry, T. Difato, D. Metzgar, S. Worthy, R. Bravo, Jennifer Thornton, R. Kruzelock, K. Mueller, Clark Tibbetts, C. Meador, Baochuan Lin, C. James, Michael J. Jenkins, Brian K. Agan, Anjan Purkayastha, E. Lawrence, Robb K. Rowley, Donald Seto, K. Grant, David A. Stenger, R. Holliday, M. Archer, F. Stotler, Chris C. Olsen, K. Gratwick, D. Pearson, L. Daum, D. Niemeyer
Rok vydání:	2005
Předmět:	Male Transcription Genetic Immunology Biology Adenovirus Infections Human Transcriptome Immune system Interferon Gene expression Cell Adhesion Genetics medicine Humans Respiratory Tract Infections Gene Genetics (clinical) Oligonucleotide Array Sequence Analysis Adenoviruses Human Gene Expression Profiling Pax genes Convalescence Gene expression profiling Military Personnel Phenotype Gene Expression Regulation Antibody Formation Humoral immunity medicine.drug
Zdroj:	Genes & Immunity. 6:588-595
ISSN:	1476-5470 1466-4879
DOI:	10.1038/sj.gene.6364244
Popis:	Gene expression profiles permit analysis of host immune response at the transcriptome level. We used the Pax gene Blood RNA (PAX) System and Affymetrix microarrays (HG-U133A&B) to survey profiles in basic military trainees and to classify them as healthy, febrile respiratory illness (FRI) without adenovirus, FRI with adenovirus, and convalescent from FRI with adenovirus. We assessed quality metrics of RNA processing for microarrays. Class prediction analysis discovered nested sets of transcripts that could categorize the phenotypes with optimized accuracy of 99% (nonfebrile vs febrile, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7449169a0ece476cdd8577e1c62369a9 https://doi.org/10.1038/sj.gene.6364244 Zobrazit plný text záznamu Plný text ve formátu PDF